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PMID: 318820 Published · ppublish English Clinical Trial Comparative Study Journal Article Randomized Controlled Trial Research Support, U.S. Gov't, P.H.S.

Clinical effect of allopurinol on preserved kidneys: a randomized double-blind study.

Annals of surgery ·Vol. 185 ·No. 1 ·1977-01-00 ·Pages 128-31

Toledo-Pereyra LH, Simmons RL, Olson LC, Najarian JS

Abstract

We investigated the clinical posttransplant effect of allopurinol on preserved kidneys. Thirty-four paired kidneys from brain-dead cadavers were preserved by hypothermic pulsatile perfusion with silica gel fraction in separate cassettes. Allopurinol was added to one perfusate and omitted from the other in a randomized, double-blind, prospective plan. There was no difference in the short-term or long-term function of either group of kidneys. Allopurinol does not appear to have as consistent a beneficial effect on non-ischemically damaged human kidneys as that observed experimentally on ischemically damaged canine organs.

MeSH Terms
Adult Allopurinol/pharmacology Cadaver Clinical Trials as Topic Female Graft Survival/drug effects Humans Kidney/drug effects Kidney Transplantation Male Organ Preservation/methods Perfusion/methods Tissue Preservation/methods Transplantation, Isogeneic
Chemicals
Allopurinol
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Toledo-Pereyra L H
Simmons R L
Olson L C
Najarian J S
References (20)
20 references, click to expand
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Article Info
Journal
Annals of surgery
Abbr.
Ann Surg
ISSN
0003-4932
DOI
10.1097/00000658-197701000-00021
Published
1977-01-00
Pages
128-31
Language
English
Region
United States
NLM ID
0372354
PMCID
PMC1396251
Subset
IM
External Links
PubMed source DOI: 10.1097/00000658-197701000-00021 PMC Full Text View journal details
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