Synthesis and antibacterial activity of N-acyl vancomycins.

The Journal of antibiotics ·Vol. 41 ·No. 10 ·1988-10-00 ·Pages 1430-8

Nagarajan R, Schabel AA, Occolowitz JL, Counter FT, Ott JL

Abstract

Several glycopeptides containing N-acyl groups have been isolated recently. We undertook the synthesis of N-acyl vancomycins, using the active ester method. The in vitro and in vivo antibacterial activity were evaluated, and structure-activity relationship of this series of semisynthetic vancomycins is discussed.

MeSH Terms

Animals Bacterial Infections/drug therapy Chemical Phenomena Chemistry In Vitro Techniques Mice Microbial Sensitivity Tests Structure-Activity Relationship Vancomycin/analogs & derivatives,chemical synthesis

Chemicals

Vancomycin

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Nagarajan R

Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285.

Schabel A A

Occolowitz J L

Counter F T

Ott J L

Article Info

Journal

The Journal of antibiotics

Abbr.

J Antibiot (Tokyo)

ISSN

0021-8820

DOI

10.7164/antibiotics.41.1430

Published

1988-10-00

Pages

1430-8

Language

English

Region

Japan

NLM ID

0151115

Subset

External Links

PubMed source DOI: 10.7164/antibiotics.41.1430 View journal details

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Synthesis and antibacterial activity of N-acyl vancomycins.

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