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PMID: 320226 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Immunohistochemical changes in morphologically involved and uninvolved colonic mucosa of patients with idiopathic proctitis.

The Journal of clinical investigation ·Vol. 59 ·No. 3 ·1977-03-00 ·Pages 379-85

Das KM, Erber WF, Rubinstein A

Abstract

Alterations in secretory component, IgA, IgG, and IgM were studied by immunofluorescent techniques in mucosal biopsy specimens obtained at colonoscopy from inflamed and grossly uninvolved colonic mucosa from 12 patients with idiopathic proctitis. Parotid-salivary secretory component and IgA and serum immunoglobulins were also investigated. Decreased secretory IgA was observed in the epithelium of all grossly involved rectal mucosa and in 40% of proximal normal mucosa. Salivary secretory IgA was not diminished. These observations suggest that a local immune defect may be pathogenetically related to idiopathic proctitis.

MeSH Terms
Adult Colon/immunology Female Fluorescent Antibody Technique Humans Immunoglobulin A Immunoglobulin Fragments Immunoglobulin G Immunoglobulin M Intestinal Mucosa/immunology Male Middle Aged Parotid Gland/immunology Proctitis/immunology Secretory Component
Chemicals
Immunoglobulin A Immunoglobulin Fragments Immunoglobulin G Immunoglobulin M Secretory Component
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Das K M
Erber W F
Rubinstein A
References (26)
26 references, click to expand
  1. Human secretory component. I. Purification of free secretory component from colostrum.
    Scand J Immunol. 1974;3(5):579-88 PMID: 4214117
  2. Mucosal and glandular distribution of immunoglobulin components: differential localization of free and bound SC in secretory epithelial cells.
    J Immunol. 1974 Apr;112(4):1553-9 PMID: 4205532
  3. The plasma cells in inflammatory disease of the colon: a quantitative study.
    J Clin Pathol. 1974 Aug;27(8):643-6 PMID: 4608917
  4. Autoantibodies to colon in rats and human ulcerative colitis: cross reactivity with Escherichia coli O:14 antigen.
    Proc Soc Exp Biol Med. 1967 Jul;125(3):975-80 PMID: 15938314
  5. Observations on idiopathic proctitis.
    Gut. 1962 Sep;3:201-6 PMID: 13929631
  6. Unusual combined immunodeficiency syndrome exhibiting kappa-IgD paraproteinemia, residual gutimmunity and graft-versus-host reaction after plasma infusion.
    Acta Paediatr Scand. 1973 Jul;62(4):365-72 PMID: 4125769
  7. Distribution of immunoglobulins in human rectal mucosa. II. Ulcerative colitis and abnormal mucosal control subjects.
    Gastroenterology. 1968 Mar;54(3):341-7 PMID: 4171112
  8. The distribution of immunoglobulin-containing cells along the human gastrointestinal tract.
    Gastroenterology. 1966 Sep;51(3):305-16 PMID: 4161535
  9. Definitions of inflammatory bowel disease of unknown etiology.
    Gastroenterology. 1975 Mar;68(3):591-600 PMID: 1112462
  10. Abnormalities in the apparently normal bowel mucosa in Crohn's disease.
    Lancet. 1976 Feb 7;1(7954):275-8 PMID: 55588
  11. Intestinal uptake of macromolecules: effect of oral immunization.
    Science. 1972 Aug 18;177(4049):608-10 PMID: 4626070
  12. Protection against enteric bacterial infection by secretory IgA antibodies.
    J Immunol. 1973 Aug;111(2):395-403 PMID: 4197984
  13. Intestinal immunoglobulins in ulcerative colitis.
    Scand J Gastroenterol. 1973;8(4):293-300 PMID: 4580813
  14. Dichotomy between immunoglobulin synthesis by cells in gut and blood of patients with hypogammaglobulinaemia.
    Lancet. 1975 Aug 9;2(7928):253-6 PMID: 49800
  15. Peripheral blood T and B cells in chronic inflammatory bowel disease.
    Gastroenterology. 1974 Oct;67(4):569-77 PMID: 4547268
  16. Immunohistochemical characterization of local immunoglobulin formation in ulcerative colitis.
    Gastroenterology. 1974 Jun;66(6):1123-36 PMID: 4829119
  17. Inhibition of bacterial adherence by secretory immunoglobulin A: a mechanism of antigen disposal.
    Science. 1972 Aug 25;177(4050):697-9 PMID: 5054144
  18. Immunochemical quantitation of antigens by single radial immunodiffusion.
    Immunochemistry. 1965 Sep;2(3):235-54 PMID: 4956917
  19. Immunological apparatus of the gut and inflammatory bowel disease.
    Gastroenterology. 1971 May;60(5):922-51 PMID: 4931956
  20. Two immunochemically and physicochemically distinct secretory components from rat exocrine secretion.
    J Immunol. 1976 Apr;116(4):994-9 PMID: 815439
  21. The distribution of mucosal antibodies in the bowel of patients with Crohn's disease.
    Gut. 1975 Feb;16(2):125-31 PMID: 1092601
  22. Secretory component deficiency. A disorder of the IgA immune system.
    N Engl J Med. 1976 Feb 12;294(7):351-6 PMID: 1107842
  23. Induction of granulomas in mice by inoculation of tissue homogenates from patients with inflammatory bowel disease and sarcoidosis.
    Ann N Y Acad Sci. 1976;278:560-4 PMID: 1067040
  24. Endogenic defense against infectious disease in chronic bronchitis.
    Respiration. 1971;28(5):480-4 PMID: 5135690
  25. Cellular hypersensitivity to components of intestinal mucosa in ulcerative colitis and Crohn's disease.
    Gut. 1969 Aug;10(8):631-6 PMID: 5810973
  26. Ulcerative proctitis and mild ulcerative colitis: A study of 220 patients.
    Medicine (Baltimore). 1966 Sep;45(5):391-412 PMID: 5975902
Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI108650
Published
1977-03-00
Pages
379-85
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC333372
Subset
IM
External Links
PubMed source DOI: 10.1172/JCI108650 PMC Full Text View journal details
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