Home LiteratureArticle Details
PMID: 32042416 Published · ppublish English Journal Article

Paternal age is affected by genetic abnormalities, perinatal complications and mental health of the offspring.

Biomedical reports ·Vol. 12 ·No. 3 ·2020-03-00 ·Pages 83-88

Janeczko D, Hołowczuk M, Orzeł A, Klatka B, Semczuk A

Abstract

Infertility and fecundity problems concern 10-18% of partners in their reproductive years compromising around one million females and males in Poland. Research and analysis of factors that affect male fertility are limited, especially, regarding the age of the father and determining the age at which quality of semen decreases. Age of the father has greater impact than maternal age, on cases of sporadic autosomal dominant congenital diseases such as Apert, Crouzon, Pfeiffer, Noonan and Costello syndromes, multiple endocrine neoplasia (types 2A and 2B) and achondroplasia. However, there are only a few reports taking paternal advanced age into consideration for pre-mature birth, low Apgar scores or admission to a neonatal intensive care department. Paternal age increases the frequency of congenital diseases such as heart malformations as well as oral, palate and lip cleft. Moreover, mental disorders (autism, schizophrenia, bipolar disorder, low IQ level as well as ADHD) also occur more frequently in advanced father's age. Advanced paternal age is defined differently in every research. It depends on disorders in offspring we are talking about. Paternal age has an impact on child's health and development and it is as significant as maternal age, when it comes to reproductive matters.

Keywords
autism congenital abnormalities infertility male mental disorders paternal age
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Janeczko Dominika
Second Department of Gynecology, Medical University of Lublin, PL-20954 Lublin, Poland.
Hołowczuk Magdalena
Second Department of Gynecology, Medical University of Lublin, PL-20954 Lublin, Poland.
Orzeł Anna
Second Department of Gynecology, Medical University of Lublin, PL-20954 Lublin, Poland.
Klatka Barbara
Second Department of Gynecology, Medical University of Lublin, PL-20954 Lublin, Poland.
Semczuk Andrzej
Second Department of Gynecology, Medical University of Lublin, PL-20954 Lublin, Poland.
References (59)
59 references, click to expand
  1. Advancing paternal age and risk of autism: new evidence from a population-based study and a meta-analysis of epidemiological studies.
    Mol Psychiatry. 2011 Dec;16(12):1203-12 PMID: 21116277
  2. Infertility in the light of new scientific reports - focus on male factor.
    Ann Agric Environ Med. 2016 Jun 2;23(2):227-30 PMID: 27294623
  3. Parental age and the risk of isolated cleft lip: a registry-based study.
    Ann Epidemiol. 2015 Dec;25(12):942-7.e1 PMID: 26092647
  4. Advancing paternal age and autism.
    Arch Gen Psychiatry. 2006 Sep;63(9):1026-32 PMID: 16953005
  5. Paternal age and mental health of offspring.
    Fertil Steril. 2015 Jun;103(6):1392-6 PMID: 25956369
  6. Advanced paternal age and stillbirth rate: a nationwide register-based cohort study of 944,031 pregnancies in Denmark.
    Eur J Epidemiol. 2017 Mar;32(3):227-234 PMID: 28271174
  7. Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations.
    Nature. 2012 Apr 04;485(7397):246-50 PMID: 22495309
  8. Advanced paternal age is associated with impaired neurocognitive outcomes during infancy and childhood.
    PLoS Med. 2009 Mar 10;6(3):e40 PMID: 19278291
  9. Patterns and rates of exonic de novo mutations in autism spectrum disorders.
    Nature. 2012 Apr 04;485(7397):242-5 PMID: 22495311
  10. Long-term effects of delayed parenthood.
    Hum Reprod. 1998 Sep;13(9):2371-6 PMID: 9806250
  11. Parent's age and the risk of oral clefts.
    Epidemiology. 2005 May;16(3):311-6 PMID: 15824545
  12. Paternal age and offspring congenital heart defects: a national cohort study.
    PLoS One. 2015 Mar 25;10(3):e0121030 PMID: 25806788
  13. Male biological clock: a critical analysis of advanced paternal age.
    Fertil Steril. 2015 Jun;103(6):1402-6 PMID: 25881878
  14. Molecular basis of maternal age-related increase in oocyte aneuploidy.
    Congenit Anom (Kyoto). 2012 Mar;52(1):8-15 PMID: 22348779
  15. Association of paternal age and risk for major congenital anomalies from the National Birth Defects Prevention Study, 1997 to 2004.
    Ann Epidemiol. 2010 Mar;20(3):241-9 PMID: 20056435
  16. Paternal risk factors for isolated membranous ventricular septal defects.
    Am J Med Genet. 1997 Jul 11;71(1):42-6 PMID: 9215767
  17. Paternal age at childbearing and offspring psychiatric and academic morbidity.
    JAMA Psychiatry. 2014 Apr;71(4):432-8 PMID: 24577047
  18. Fathers Count: The Impact of Paternal Risk Factors on Birth Outcomes.
    Matern Child Health J. 2018 Mar;22(3):401-408 PMID: 29218490
  19. Effect of fathers' age and birth order on occurrence of congenital heart disease.
    J Epidemiol Community Health. 1991 Dec;45(4):299-301 PMID: 1795151
  20. Paternal age and the risk of congenital heart defects.
    Teratology. 1994 Jul;50(1):80-4 PMID: 7974258
  21. Paternal age and schizophrenia: a population based cohort study.
    BMJ. 2004 Nov 6;329(7474):1070 PMID: 15501901
  22. Paternal aging and increased risk of congenital disease, psychiatric disorders, and cancer.
    Asian J Androl. 2016 May-Jun;18(3):420-4 PMID: 26975491
  23. Parental age and risk of schizophrenia: a case-control study.
    Arch Gen Psychiatry. 2003 Jul;60(7):673-8 PMID: 12860771
  24. Paternal factors and schizophrenia risk: de novo mutations and imprinting.
    Schizophr Bull. 2001;27(3):379-93 PMID: 11596842
  25. Prevalence of congenital heart defects in metropolitan Atlanta, 1998-2005.
    J Pediatr. 2008 Dec;153(6):807-13 PMID: 18657826
  26. Paternal age and intelligence: implications for age-related genomic changes in male germ cells.
    Psychiatr Genet. 2005 Jun;15(2):117-25 PMID: 15900226
  27. Advancing paternal age and simplex autism.
    Autism. 2012 Jul;16(4):367-80 PMID: 22180389
  28. Paternal age and congenital malformations.
    Hum Reprod. 2005 Nov;20(11):3173-7 PMID: 16006461
  29. Advanced paternal age and risk of psychotic-like symptoms in adult offspring.
    Schizophr Res. 2015 Jul;165(2-3):123-7 PMID: 25972109
  30. Perinatal factors and the development of autism: a population study.
    Arch Gen Psychiatry. 2004 Jun;61(6):618-27 PMID: 15184241
  31. Advancing paternal age and bipolar disorder.
    Arch Gen Psychiatry. 2008 Sep;65(9):1034-40 PMID: 18762589
  32. Risk factors for congenital heart diseases in Alexandria, Egypt.
    Eur J Epidemiol. 2000;16(9):805-14 PMID: 11297222
  33. Parental age as a risk factor for isolated congenital malformations in a Polish population.
    Paediatr Perinat Epidemiol. 2009 Jan;23(1):29-40 PMID: 19228312
  34. Autism risk across generations: a population-based study of advancing grandpaternal and paternal age.
    JAMA Psychiatry. 2013 May;70(5):516-21 PMID: 23553111
  35. A comprehensive assessment of parental age and psychiatric disorders.
    JAMA Psychiatry. 2014 Mar;71(3):301-9 PMID: 24452535
  36. Parental age and the risk of autism spectrum disorders: findings from a Swedish population-based cohort.
    Int J Epidemiol. 2014 Feb;43(1):107-15 PMID: 24408971
  37. Age-related decline in sperm deoxyribonucleic acid integrity in patients evaluated for male infertility.
    Fertil Steril. 2006 Feb;85(2):496-9 PMID: 16595239
  38. A unique view on male infertility around the globe.
    Reprod Biol Endocrinol. 2015 Apr 26;13:37 PMID: 25928197
  39. Paternal sperm DNA methylation associated with early signs of autism risk in an autism-enriched cohort.
    Int J Epidemiol. 2015 Aug;44(4):1199-210 PMID: 25878217
  40. Paternal age effect mutations and selfish spermatogonial selection: causes and consequences for human disease.
    Am J Hum Genet. 2012 Feb 10;90(2):175-200 PMID: 22325359
  41. Patterns in the prevalence of congenital heart defects, metropolitan Atlanta, 1978 to 2005.
    Birth Defects Res A Clin Mol Teratol. 2013 Feb;97(2):87-94 PMID: 23404870
  42. Paternal age and preterm birth in Italy, 1990 to 1998.
    Epidemiology. 2006 Mar;17(2):218-21 PMID: 16477263
  43. Rate of de novo mutations and the importance of father's age to disease risk.
    Nature. 2012 Aug 23;488(7412):471-5 PMID: 22914163
  44. Paternal Age Alters Social Development in Offspring.
    J Am Acad Child Adolesc Psychiatry. 2017 May;56(5):383-390 PMID: 28433087
  45. The origins, patterns and implications of human spontaneous mutation.
    Nat Rev Genet. 2000 Oct;1(1):40-7 PMID: 11262873
  46. Maternal age and paternal age are associated with distinct childhood behavioural outcomes in a general population birth cohort.
    Schizophr Res. 2009 Dec;115(2-3):130-5 PMID: 19781913
  47. National time trends in congenital heart defects, Denmark, 1977-2005.
    Am Heart J. 2009 Mar;157(3):467-473.e1 PMID: 19249416
  48. De novo gene disruptions in children on the autistic spectrum.
    Neuron. 2012 Apr 26;74(2):285-99 PMID: 22542183
  49. Paternal age and risk of schizophrenia in adult offspring.
    Am J Psychiatry. 2002 Sep;159(9):1528-33 PMID: 12202273
  50. Paternal age and psychiatric disorders: findings from a Dutch population registry.
    Schizophr Res. 2011 Jul;129(2-3):128-32 PMID: 21489755
  51. Paternal age and birth defects: how strong is the association?
    Hum Reprod. 2007 Mar;22(3):696-701 PMID: 17164268
  52. [Prevalence of congenital heart disease in 44,985 newborns in Colombia].
    Arch Cardiol Mex. 2006 Jul-Sep;76(3):263-8 PMID: 17091797
  53. Advanced paternal age and risk of fetal death: a cohort study.
    Am J Epidemiol. 2004 Dec 15;160(12):1214-22 PMID: 15583374
  54. Advancing paternal age and the risk of schizophrenia.
    Arch Gen Psychiatry. 2001 Apr;58(4):361-7 PMID: 11296097
  55. The effect of paternal age on fetal birth outcomes.
    Am J Mens Health. 2012 Sep;6(5):427-35 PMID: 22564913
  56. De novo mutations revealed by whole-exome sequencing are strongly associated with autism.
    Nature. 2012 Apr 04;485(7397):237-41 PMID: 22495306
  57. Association of paternal age with perinatal outcomes between 2007 and 2016 in the United States: population based cohort study.
    BMJ. 2018 Oct 31;363:k4372 PMID: 30381468
  58. Strong association of de novo copy number mutations with autism.
    Science. 2007 Apr 20;316(5823):445-9 PMID: 17363630
  59. Risk factors for cardiovascular malformation--a study based on prospectively collected data.
    Scand J Work Environ Health. 2002 Feb;28(1):12-7 PMID: 11873776
Article Info
Journal
Biomedical reports
Abbr.
Biomed Rep
ISSN
2049-9434
DOI
10.3892/br.2019.1266
Published
2020-03-00
Epub
2019-00-20
Pages
83-88
Language
English
Region
England
NLM ID
101613227
PMCID
PMC7006092
External Links
PubMed source DOI: 10.3892/br.2019.1266 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2