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PMID: 3210010 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Capsaicin-sensitive vasodilatatory mechanisms in the rat substantia nigra and striatum.

Journal of neural transmission ·Vol. 74 ·No. 3 ·1988-00-00 ·Pages 129-39

Hajós M, Engberg G, Nissbrandt H, Magnusson T, Carlsson A

Abstract

Thermoregulatory and neurochemical effects of capsaicin microinjection into the substantia nigra (SN) or caudatus putamen (CPu) were studied in rats. Administration of capsaicin into these brain structures induced a peripheral vasodilatation which was associated with a decrease in body temperature. Pretreatment of the rats with capsaicin either as adults or neonates abolished the thermolytic response to the drug, indicating that the effect is executed specifically upon capsaicin sensitive structures. Analyses of the levels of monoamines and their metabolites in the striatum following injection of capsaicin into the SN or CPu revealed that dopaminergic neurons are not primarily involved in this effect. This view is also supported by our findings that neurochemical lesion of unilateral nigrostriatal dopaminergic neurons did not influence the vasodilatatory response. Since the pharmacological effect of intranigral capsaicin was not abolished by unilateral axotomy (hemisection) we presume a capsaicin-sensitive, non-dopaminergic descending vasodilatatory pathway from the SN.

MeSH Terms
Action Potentials/drug effects Animals Body Temperature Regulation/drug effects Capsaicin/pharmacology Corpus Striatum/drug effects,metabolism,physiology Dopamine/metabolism Dose-Response Relationship, Drug Male Rats Rats, Inbred Strains Substantia Nigra/drug effects,metabolism,physiology Vasodilation/drug effects
Chemicals
Capsaicin Dopamine
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Hajós M
Department of Pharmacology, University of Göteborg, Sweden.
Engberg G
Nissbrandt H
Magnusson T
Carlsson A
References (29)
29 references, click to expand
  1. Differences in the mechanisms of the thermoregulatory impairment induced by capsaicin in newborn and adult rats.
    Acta Physiol Hung. 1987;69(3-4):437-45 PMID: 3661220
  2. Effect of ethanol on the hydroxylation of tyrosine and tryptophan in rat brain in vivo.
    J Pharm Pharmacol. 1973 Jun;25(6):437-40 PMID: 4146580
  3. The effects of selective dopamine receptor agonists and antagonists on body temperature in rats.
    Eur J Pharmacol. 1987 Jan 20;133(3):243-7 PMID: 2951265
  4. Dissociation between peripheral and central heat loss mechanisms induced by neonatal capsaicin.
    Behav Neurosci. 1983 Oct;97(5):822-5 PMID: 6639750
  5. Central and peripheral thermal control of effectors in homeothermic temperature regulation.
    Physiol Rev. 1986 Apr;66(2):235-300 PMID: 3008202
  6. Administration of prostaglandin E2 into the striatum induces hyperthermia in rats.
    Exp Neurol. 1984 Aug;85(2):391-9 PMID: 6589168
  7. Simultaneous determination of dopamine, DOPAC and homovanillic acid. Direct injection of supernatants from brain tissue homogenates in a liquid chromatography--electrochemical detection system.
    J Chromatogr. 1980 Dec 12;221(2):237-47 PMID: 7217293
  8. Determination of catecholamines in rat brain parts by reverse-phase ion-pair liquid chromatography.
    J Neurochem. 1978 Dec;31(6):1461-5 PMID: 551126
  9. Vasodilatation on preoptic heating in capsaicin-treated rats.
    Experientia. 1983 Feb 15;39(2):221-3 PMID: 6832303
  10. Stimulation and desensitization of the hypothalamic heat-sensitive structures by capsaicin in rats.
    J Physiol. 1970 Jun;208(2):449-59 PMID: 5500735
  11. Temperature regulation and dopaminergic systems in the brain: does the substantia nigra play a role?
    Brain Res. 1982 Feb 25;234(2):275-86 PMID: 7059831
  12. Hypothalamic and striatal dopamine receptor activation inhibits heat production in the rat.
    Am J Physiol. 1982 May;242(5):R471-81 PMID: 7081473
  13. Different roles of intrahypothalamic and nigrostriatal dopaminergic systems in thermoregulatory responses of the rat.
    Life Sci. 1986 Aug 25;39(8):707-15 PMID: 3736342
  14. Capsaicin and central control of thermoregulation.
    Pharmacol Ther. 1984;26(3):389-416 PMID: 6085515
  15. Stereotaxic mapping of the monoamine pathways in the rat brain.
    Acta Physiol Scand Suppl. 1971;367:1-48 PMID: 4109331
  16. Injection of capsaicin into the nucleus raphe dorsalis elicits heat loss in the rat.
    Neurosci Lett. 1987 Mar 31;75(2):199-204 PMID: 2437500
  17. Dopamine and thermoregulation: an evaluation with special reference to dopaminergic pathways.
    Neurosci Biobehav Rev. 1985 Winter;9(4):589-98 PMID: 3001601
  18. Neural processes in thermoregulation.
    Physiol Rev. 1973 Oct;53(4):948-1017 PMID: 4355518
  19. Intranigral injection of capsaicin enhances motor activity and depletes nigral 5-hydroxytryptamine but not substance P.
    Neuropharmacology. 1981 Apr;20(4):341-6 PMID: 6170024
  20. Selective degeneration by capsaicin of a subpopulation of primary sensory neurons in the adult rat.
    Neurosci Lett. 1985 Aug 30;59(2):209-14 PMID: 4058794
  21. An electrophysiological analysis of the actions of the 3-PPP enantiomers on the nigrostriatal dopamine system.
    Naunyn Schmiedebergs Arch Pharmacol. 1985 Jun;329(4):344-54 PMID: 4033804
  22. Autonomic deficits in Parkinson's syndrome.
    Arch Neurol. 1971 Jan;24(1):50-7 PMID: 5539987
  23. The capsaicin sensitivity of the preoptic region is preserved in adult rats pretreated as neonates, but lost in rats pretreated as adults.
    Naunyn Schmiedebergs Arch Pharmacol. 1983 Nov;324(3):219-22 PMID: 6656893
  24. Efferent connections of the substantia nigra and ventral tegmental area in the rat.
    Brain Res. 1979 Oct 19;175(2):191-217 PMID: 314832
  25. Effects of capsaicin on central monoaminergic mechanisms in the rat.
    J Neural Transm. 1986;66(3-4):221-42 PMID: 3023547
  26. Substance P release from spinal cord slices by capsaicin.
    Life Sci. 1979 Aug 13;25(7):629-36 PMID: 502756
  27. Distribution of chemosensitive primary sensory afferents in the central nervous system of the rat.
    J Comp Neurol. 1980 Apr 15;190(4):781-92 PMID: 7400386
  28. Neurotoxic action of capsaicin on spinal substance P neurons.
    Brain Res. 1980 Mar 31;186(2):435-44 PMID: 6153557
  29. Striatal neuronal responses to scrotal temperature changes and dopaminergic drugs.
    Am J Physiol. 1985 Jan;248(1 Pt 2):R108-12 PMID: 3970181
Article Info
Journal
Journal of neural transmission
Abbr.
J Neural Transm
DOI
10.1007/BF01244779
Published
1988-00-00
Pages
129-39
Language
English
Region
Austria
NLM ID
0337042
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01244779
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