A defect of the alternative pathway of complement.

Clinical and experimental immunology ·Vol. 27 ·No. 1 ·1977-01-00 ·Pages 30-3

Soothill JF, Harvey BA

Abstract

The sera of patients defective at opsonization for yeast phagocytosis fix haemolytic complement poorly following incubation with the alternative pathway complement activators, inulin and bacterial endotoxin. This suggests that the defect lies early in the alternative pathway of complement.

MeSH Terms

Adult Child Child, Preschool Complement Fixation Tests Complement System Proteins/metabolism Endotoxins Humans Infant Inulin Middle Aged Opsonin Proteins Phagocytosis Saccharomyces cerevisiae/immunology

Chemicals

Endotoxins Opsonin Proteins Inulin Complement System Proteins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Soothill J F

Harvey B A

References (3)

3 references, click to expand

The properdin system and immunity. I. Demonstration and isolation of a new serum protein, properdin, and its role in immune phenomena.
Science. 1954 Aug 20;120(3112):279-85 PMID: 13186838
Defective opsonization. A common immunity deficiency.
Arch Dis Child. 1976 Feb;51(2):91-9 PMID: 769701
A familial deficiency of the phagocytosis-enhancing activity of serum related to a dysfunction of the fifth component of complement (C5).
N Engl J Med. 1970 Feb 12;282(7):354-8 PMID: 5411128

Article Info

Journal

Clinical and experimental immunology

Abbr.

Clin Exp Immunol

ISSN

0009-9104

Published

1977-01-00

Pages

30-3

Language

English

Region

England

NLM ID

0057202

PMCID

PMC1540913

Subset

External Links

PubMed source PMC Full Text View journal details

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A defect of the alternative pathway of complement.

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