Biological properties of Shigella flexneri 2A toxin and its serological relationship to Shigella dysenteriae 1 toxin.

Infection and immunity ·Vol. 15 ·No. 3 ·1977-03-00 ·Pages 796-8

O'Brien AD, Thompson MR, Gemski P, Doctor BP, Formal SB

Abstract

A toxin extracted from heat-inactivated, alkaline-treated Shigella flexneri 2a showed biological properties similar to those of Shigella dysenteria 1 toxin. The S, flexneri 2a toxin was lethal to mice, enterotoxic for ileal loops of rabbits, and cytotoxic for HeLa cells. A serological relationship between S. flexneri 2a and S. dysenteriae 1 toxin was shown with cross neutralization tests.

MeSH Terms

Antigens, Bacterial Bacterial Toxins Cross Reactions Neutralization Tests Shigella dysenteriae/immunology Shigella flexneri/immunology

Chemicals

Antigens, Bacterial Bacterial Toxins

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

O'Brien A D

Thompson M R

Gemski P

Doctor B P

Formal S B

References (9)

9 references, click to expand

The action of the thermolabile toxin of Shigella dysenteriae on cells cultivated in vitro.
Br J Exp Pathol. 1960 Apr;41:179-89 PMID: 13842077
USE OF LIGATED SEGMENTS OF RABBIT SMALL INTESTINE IN EXPERIMENTAL SHIGELLOSIS.
J Bacteriol. 1965 Mar;89:803-9 PMID: 14273664
Studies with Vibrio cholerae in the ligated loop of the rabbit intestine.
Br J Exp Pathol. 1961 Oct;42:504-10 PMID: 13894076
The neurotoxin of Shigella shigae. I. Production, purification and properties of the toxin.
Br J Exp Pathol. 1953 Apr;34(2):202-16 PMID: 13051531
Protein measurement with the Folin phenol reagent.
J Biol Chem. 1951 Nov;193(1):265-75 PMID: 14907713
Shigellosis due to Shigella dysenteriae. 1. Relative importance of mucosal invasion versus toxin production in pathogenesis.
J Infect Dis. 1972 Nov;126(5):523-30 PMID: 4197755
The pathogenesis of Shigella diarrhea. I. Enterotoxin production by Shigella dysenteriae I.
J Clin Invest. 1972 May;51(5):1212-8 PMID: 4560429
Fluorescent-antibody and histological study of vaccinated and control monkeys challenged with Shigella flexneri.
J Bacteriol. 1966 Jun;91(6):2368-76 PMID: 4957617
Inhibition of in vitro protein synthesis by Shigella dysenteriae 1 toxin.
Biochem Biophys Res Commun. 1976 Aug 9;71(3):783-8 PMID: 786292

Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.15.3.796-798.1977

Published

1977-03-00

Pages

796-8

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC421442

Subset

External Links

PubMed source DOI: 10.1128/iai.15.3.796-798.1977 PMC Full Text View journal details

Analysis Services

Biological properties of Shigella flexneri 2A toxin and its serological relationship to Shigella dysenteriae 1 toxin.

Contact

WeChat Official Account