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PMID: 3257586 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

One factor recognizes the liver-specific enhancers in alpha 1-antitrypsin and transthyretin genes.

Science (New York, N.Y.) ·Vol. 239 ·No. 4841 Pt 1 ·1988-02-12 ·Pages 786-8

Grayson DR, Costa RH, Xanthopoulos KG, Darnell JE

Abstract

Four different regulatory sites required for transcriptional stimulation by the enhancers of two unrelated liver-specific genes alpha 1-antitrypsin and transthyretin appear to bind the same nuclear protein that is found mainly in the liver. Such proteins may provide a basis for a coordinated, hepatocyte-specific control of gene transcription.

MeSH Terms

Animals Enhancer Elements, Genetic Gene Expression Regulation Genes Genes, Regulator Liver/metabolism Mice Mutation Nuclear Proteins/physiology Prealbumin/genetics Transcription, Genetic alpha 1-Antitrypsin/genetics

Chemicals

Nuclear Proteins Prealbumin alpha 1-Antitrypsin

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Grayson D R

Rockefeller University, New York, NY 10021.

Costa R H

Xanthopoulos K G

Darnell J E

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.3257586

Published

1988-02-12

Pages

786-8

Language

English

Region

United States

NLM ID

0404511

Subset

Grants

NCI NIH HHS · CA 160006-14 · United States

NCI NIH HHS · CA 18213-11 · United States

NIGMS NIH HHS · GM 1066-02 · United States

External Links

PubMed source DOI: 10.1126/science.3257586 View journal details

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One factor recognizes the liver-specific enhancers in alpha 1-antitrypsin and transthyretin genes.

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