Gene transactivation mediated by the TAT gene of human immunodeficiency virus in transgenic mice.

Nucleic acids research ·Vol. 16 ·No. 4 ·1988-02-25 ·Pages 1423-30

Khillan JS, Deen KC, Yu SH, Sweet RW, Rosenberg M, Westphal H

Abstract

Transgenic mice were generated carrying either the long terminal repeat of Human Immunodeficiency Virus fused to the bacterial chloramphenicol acetyl transferase reporter gene or a control element of the murine alpha A crystallin gene fused to the tat gene of human immunodeficiency virus. By crossing these two strains, progeny were obtained which carried both transgenes. The bacterial reporter gene was specifically transactivated in the eyes of these animals.

MeSH Terms

Acetyltransferases/genetics Animals Chloramphenicol O-Acetyltransferase Cloning, Molecular Crystallins/genetics Gene Expression Regulation Gene Products, rev Genes Genes, Viral Genetic Vectors HIV/genetics Mice Mice, Transgenic Retroviridae Proteins/genetics rev Gene Products, Human Immunodeficiency Virus

Chemicals

Crystallins Gene Products, rev Retroviridae Proteins rev Gene Products, Human Immunodeficiency Virus Acetyltransferases Chloramphenicol O-Acetyltransferase

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Khillan J S

Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, MD 20892.

Deen K C

Yu S H

Sweet R W

Rosenberg M

Westphal H

References (19)

19 references, click to expand

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Article Info

Journal

Nucleic acids research

Abbr.

Nucleic Acids Res

ISSN

0305-1048

DOI

10.1093/nar/16.4.1423

Published

1988-02-25

Pages

1423-30

Language

English

Region

England

NLM ID

0411011

PMCID

PMC336325

Subset

External Links

PubMed source DOI: 10.1093/nar/16.4.1423 PMC Full Text View journal details

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Gene transactivation mediated by the TAT gene of human immunodeficiency virus in transgenic mice.

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