Production of B cell stimulatory factor-2/interleukin-6 activity by human endothelial cells.

Biochemical and biophysical research communications ·Vol. 153 ·No. 3 ·1988-06-30 ·Pages 1045-50

Norioka K, Hara M, Harigai M, Kitani A, Hirose T, Suzuki K, Kawakami M, Tabata H, Kawagoe M, Nakamura H

Abstract

The effect of culture supernatants of endothelial cell (EC) lines on the immunoglobulin-M(IgM) synthesis by human B cell line, SKW6-CL4 cells, was investigated. Supernatants of human EC stimulated IgM synthesis, as high as 6-fold, but supernatants of bovine EC did not. This enhancing activity was completely blocked by addition of anti-human B cell stimulatory factor-2/interleukin-6 (BSF-2/IL-6) antibody. These data suggest that human EC might participate in the human antibody production system by producing soluble factor, BSF-2/IL-6.

MeSH Terms

Animals Antibodies Cell Line Endothelium, Vascular/metabolism Humans Immunoglobulin M/biosynthesis Interleukin-6 Interleukins/biosynthesis Rabbits

Chemicals

Antibodies Immunoglobulin M Interleukin-6 Interleukins

Authors & Affiliations

10 authors, click to expand affiliations / ORCID

Norioka K

First Department of Internal Medicine, National Defense Medical College, Saitama, Japan.

Hara M

Harigai M

Kitani A

Hirose T

Suzuki K

Kawakami M

Tabata H

Kawagoe M

Nakamura H

Article Info

Journal

Biochemical and biophysical research communications

Abbr.

Biochem Biophys Res Commun

ISSN

0006-291X

DOI

10.1016/s0006-291x(88)81334-2

Published

1988-06-30

Pages

1045-50

Language

English

Region

United States

NLM ID

0372516

Subset

Corrections

ErratumIn

External Links

PubMed source DOI: 10.1016/s0006-291x(88)81334-2 View journal details

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Production of B cell stimulatory factor-2/interleukin-6 activity by human endothelial cells.

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