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PMID: 326444 Published · ppublish English Comparative Study Journal Article

Rheumatoid factor plaque-forming cells in rheumatoid synovial tissue.

Clinical and experimental immunology ·Vol. 28 ·No. 2 ·1977-05-00 ·Pages 197-203

Taylor-Upsahl MM, Abrahamsen TG, Natvig JB

Abstract

Cells producing rheumatoid factor (RF) were readily detected in vitro by means of a haemolytic plaque assay system employing sheep erythrocytes (SRBC) sensitized with reduced and alkylated rabbit IgG anti-SRBC antibody as target cells. Rheumatoid factor-producing, plaque-forming cells (RF-PFC) were observed in all of the synovial tissue cell preparations from seropositive rheumatoid arthritis patients studied. The numbers of RF-PFC varied considerably without any direct correlation with serum titres of RF antibody activity. However, high numbers of RF-PFC were never found in patients with low rheumatoid factor titres whereas, high and low numbers of RF-PFC were found among the patients with high RF titres. Synovial tissue cell preparations from a group of seronegative patients, with only one exception, failed to exhibit RF-PFC.

MeSH Terms
Adolescent Adult Aged Antibody-Producing Cells/immunology Arthritis, Rheumatoid/immunology Cell Count Child Erythrocytes/immunology Female Hemolytic Plaque Technique Humans Immunoglobulin G Male Middle Aged Rheumatoid Factor/analysis Synovial Membrane/immunology
Chemicals
Immunoglobulin G Rheumatoid Factor
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Taylor-Upsahl M M
Abrahamsen T G
Natvig J B
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24 references, click to expand
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Article Info
Journal
Clinical and experimental immunology
Abbr.
Clin Exp Immunol
ISSN
0009-9104
Published
1977-05-00
Pages
197-203
Language
English
Region
England
NLM ID
0057202
PMCID
PMC1540764
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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