Genetic defect in responsiveness to the B cell mitogen lipopolysaccharide.

European journal of immunology ·Vol. 7 ·No. 5 ·1977-05-00 ·Pages 325-8

Coutinho A, Forni L, Melchers F, Watanabe T

Abstract

Splenic B cells C57BL/10ScCr mice fail to respond to the mitogenic principle of lipopolysaccharide (LPS), and do not express a serologically defined "LPS receptor". In contrast, polyclonal B cell responses to both purified protein derivative of tuberculin and lipoprotein are conserved.

MeSH Terms

Animals Antibody Formation B-Lymphocytes/immunology Cells, Cultured Fluorescent Antibody Technique Genes Lipopolysaccharides/pharmacology Mice Mice, Inbred Strains Mitogens Mutation Spleen/immunology

Chemicals

Lipopolysaccharides Mitogens

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Coutinho A

Forni L

Melchers F

Watanabe T

Article Info

Journal

European journal of immunology

Abbr.

Eur J Immunol

ISSN

0014-2980

DOI

10.1002/eji.1830070517

Published

1977-05-00

Pages

325-8

Language

English

Region

Germany

NLM ID

1273201

Subset

External Links

PubMed source DOI: 10.1002/eji.1830070517 View journal details

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Genetic defect in responsiveness to the B cell mitogen lipopolysaccharide.

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