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PMID: 327545 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

A bactericidal effect for human lactoferrin.

Science (New York, N.Y.) ·Vol. 197 ·No. 4300 ·1977-07-15 ·Pages 263-5

Arnold RR, Cole MF, McGhee JR

Abstract

Streptococcus mutans and Vibrio cholerae, but not Escherichia coli, were killed by incubation with purified human apolactoferrin. Concentrations of lactoferrin below that necessary for total inhibition resulted in a marked reduction in viable colony-forming units. This bactericidal effect was contingent upon the metal-chelating properties of the lactoferrin molecule.

MeSH Terms

Apoproteins/pharmacology Chelating Agents/pharmacology Dose-Response Relationship, Drug Escherichia coli/drug effects Humans Iron/metabolism Lactoferrin/pharmacology Lactoglobulins/pharmacology Species Specificity Streptococcus/drug effects Streptococcus mutans/drug effects Vibrio cholerae/drug effects

Chemicals

Apoproteins Chelating Agents Lactoglobulins Iron Lactoferrin

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Arnold R R

Cole M F

McGhee J R

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.327545

Published

1977-07-15

Pages

263-5

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.327545 View journal details

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A bactericidal effect for human lactoferrin.

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