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PMID: 3300543 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Activity of phenothiazines against medically important yeasts.

Antimicrobial agents and chemotherapy ·Vol. 31 ·No. 5 ·1987-05-00 ·Pages 834-6

Eilam Y, Polacheck I, Ben-Gigi G, Chernichovsky D

Abstract

Two phenothiazine compounds, trifluoperazine and chlorpromazine, inhibited growth in vitro of the five most common pathogenic yeasts, with MICs ranging from 10 to 40 micrograms/ml. Daily intraperitoneal injections of trifluoperazine (4 to 7 mg/kg of body weight) increased the survival of mice experimentally infected with Candida albicans or Cryptococcus neoformans. The potential use of these drugs against fungal meningitis is discussed.

MeSH Terms
Animals Candida/drug effects,growth & development Candida albicans/drug effects,growth & development Candidiasis/drug therapy Chlorpromazine/pharmacology Cryptococcosis/drug therapy Cryptococcus/drug effects Cryptococcus neoformans/drug effects,growth & development Female Humans Mice Trifluoperazine/pharmacology
Chemicals
Trifluoperazine Chlorpromazine
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Eilam Y
Polacheck I
Ben-Gigi G
Chernichovsky D
References (10)
10 references, click to expand
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.31.5.834
Published
1987-05-00
Pages
834-6
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC174848
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.31.5.834 PMC Full Text View journal details
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