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PMID: 33007276 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

CFD-DEM -DDM Model for Spray Coating Process in a Wurster Coater.

Journal of pharmaceutical sciences ·Vol. 109 ·No. 12 ·2020-00-00 ·Pages 3678-3689

Farivar F, Zhang H, Tian ZF, Gupte A

Abstract

A multiscale model by coupling computational fluid dynamics (CFD) with a discrete element model (DEM) and discrete droplet model (DDM) is developed to simulate a lab-scale Wurster coater. Two case studies are conducted to study the effect of particle shape in the system. In the first case study, 45,000 spherical particles are coated for 5 s while for the second case study, a mixture of 22,500 spherical particles and 22,500 cylindrical particles is simulated. The residence time distributions (RTD) of particles in different spray zones are compared, and the best spray zone is derived by analysing the positions of spray droplet-particle contacts. The simulation results show that the RTD of the particles within an accurate spray zone can provide valuable information on the final product's particles size distribution. Furthermore, the coefficient of variation (COV) for the coating mass received by the particles is studied for both case studies.

Keywords
CFD-DEM Fluidized bed Simulation Spray coating
MeSH Terms
Computer Simulation Drug Compounding/instrumentation Equipment Design Hydrodynamics Models, Chemical Particle Size Powders Technology, Pharmaceutical/instrumentation
Chemicals
Powders
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Farivar Foad
School of Chemical Engineering, The University of Adelaide, Adelaide, SA 5005, Australia. Electronic address: [email protected].
Zhang Hu
School of Chemical Engineering, The University of Adelaide, Adelaide, SA 5005, Australia; Amgen Bioprocessing Centre, Keck Graduate Institute, Claremont, CA 91711, USA.
Tian Zhao F
School of Mechanical Engineering, The University of Adelaide, Adelaide, SA 5005, Australia.
Gupte Anshul
Mayne Pharma, Salisbury South, Adelaide, SA 5106, Australia.
Article Info
Journal
Journal of pharmaceutical sciences
Abbr.
J Pharm Sci
ISSN
1520-6017
Published
2020-00-00
Epub
2020-00-29
Pages
3678-3689
Language
English
Region
United States
NLM ID
2985195R
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