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PMID: 3301401 Published · ppublish English Journal Article

Role of Mg2+ in the ribozyme system.

FEBS letters ·Vol. 219 ·No. 2 ·1987-07-27 ·Pages 279-82

Toh H, Imamura A, Kanda K

Abstract

Recently, several kinds of catalytic activities have been identified from L-19 IVS RNA or 'ribozyme'. In the catalytic process of ribozyme, Mg2+ is required. We investigated the role of Mg2+ by molecular orbital calculation. Based on the results of the calculation, a model for the self-splicing reaction was constructed.

MeSH Terms
Animals Kinetics Magnesium/pharmacology RNA Splicing/drug effects RNA, Catalytic RNA, Ribosomal/drug effects,metabolism Tetrahymena/genetics
Chemicals
RNA, Catalytic RNA, Ribosomal Magnesium
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Toh H
Imamura A
Kanda K
Article Info
Journal
FEBS letters
Abbr.
FEBS Lett
ISSN
0014-5793
DOI
10.1016/0014-5793(87)80235-1
Published
1987-07-27
Pages
279-82
Language
English
Region
England
NLM ID
0155157
Subset
IM
Corrections
ErratumIn
-
External Links
PubMed source DOI: 10.1016/0014-5793(87)80235-1 View journal details
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