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PMID: 3316038 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Extensive homology between the leukotoxin of Pasteurella haemolytica A1 and the alpha-hemolysin of Escherichia coli.

Infection and immunity ·Vol. 55 ·No. 12 ·1987-12-00 ·Pages 3233-6

Strathdee CA, Lo RY

Abstract

The 19.8- and 101.9-kilodalton leukotoxin proteins of Pasteurella haemolytica (LKTC and LKTA, respectively) share extensive homology with the HLYC and HLYA alpha-hemolysin proteins of Escherichia coli. The leukotoxin LKTA protein cross-reacts with hemolysin-specific antisera in Western blot (immunoblot) analysis, indicating that it shares epitopes with the alpha-hemolysin HLYA protein. Both LKTA and HLYA contain a conserved hydrophobic region, as well as a set of tandemly repeated domains. These features have been implicated in the lytic function of the alpha-hemolysin.

MeSH Terms
Amino Acid Sequence Bacterial Proteins/immunology Cross Reactions Escherichia coli/pathogenicity Escherichia coli Proteins Exotoxins/immunology Hemolysin Proteins Molecular Sequence Data Pasteurella/pathogenicity Protein Conformation Solubility
Chemicals
Bacterial Proteins Escherichia coli Proteins Exotoxins Hemolysin Proteins Hlya protein, E coli leukotoxin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Strathdee C A
Department of Microbiology, University of Guelph, Ontario, Canada.
Lo R Y
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22 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.55.12.3233-3236.1987
Published
1987-12-00
Pages
3233-6
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC260059
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.55.12.3233-3236.1987 PMC Full Text View journal details
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