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PMID: 333443 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Mutator action by Escherichia coli strains carrying dnaE mutations.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 74 ·No. 9 ·1977-09-00 ·Pages 3947-50

Sevastopoulos CG, Glaser DA

Abstract

Several newly isolated temperature-sensitive dnaE mutants of Escherichia coli exhibit powerful mutagenic action at permissive temperatures. Mutation rates for the two most active mutants were assayed at four different temperatures and compared to wild-type behavior. Temperature-resistant revertants of the original temperature-sensitive dnaE mutants exhibited lower, nearly normal, mutation rates, but no antimutator strains were found.

MeSH Terms

Ampicillin DNA-Directed DNA Polymerase/genetics Escherichia coli/genetics Mutation Penicillin Resistance Species Specificity Temperature

Chemicals

Ampicillin DNA-Directed DNA Polymerase

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Sevastopoulos C G

Glaser D A

References (17)

17 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.74.9.3947

Published

1977-09-00

Pages

3947-50

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC431795

Subset

External Links

PubMed source DOI: 10.1073/pnas.74.9.3947 PMC Full Text View journal details

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