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PMID: 3340147 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

A tissue-specific endothelial cell molecule involved in lymphocyte homing.

Nature ·Vol. 331 ·No. 6151 ·1988-01-07 ·Pages 41-6

Streeter PR, Berg EL, Rouse BT, Bargatze RF, Butcher EC

Abstract

An endothelial cell surface molecule that is selectively expressed in mucosal organs is required for lymphocyte homing to mucosal lymphoid tissues. This 'vascular addressin' appears to function as a tissue-specific marker or address signal for recognition by lymphocytes circulating in the blood.

MeSH Terms

Animals Antibodies, Monoclonal/immunology Antigens, Surface Cadherins Cell Adhesion Cell Adhesion Molecules Cell Movement Endothelium, Vascular/analysis,immunology Lymph Nodes/metabolism Lymphocytes/physiology Membrane Glycoproteins/immunology,physiology Mice Mice, Inbred BALB C Organ Specificity Peyer's Patches/metabolism

Chemicals

Antibodies, Monoclonal Antigens, Surface Cadherins Cdh2 protein, mouse Cell Adhesion Molecules Membrane Glycoproteins

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Streeter P R

Department of Pathology, Stanford University School of Medicine, California 94305.

Berg E L

Rouse B T

Bargatze R F

Butcher E C

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/331041a0

Published

1988-01-07

Pages

41-6

Language

English

Region

England

NLM ID

0410462

Subset

External Links

PubMed source DOI: 10.1038/331041a0 View journal details

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A tissue-specific endothelial cell molecule involved in lymphocyte homing.

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