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PMID: 3340187 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Temporal pattern of alcohol dehydrogenase gene transcription reproduced by Drosophila stage-specific embryonic extracts.

Nature ·Vol. 331 ·No. 6155 ·1988-02-04 ·Pages 410-5

Heberlein U, Tjian R

Abstract

Regulation of transcription during development has been analysed in vitro using extracts derived from Drosophila embryos. Transcription of mutant templates reveals cis-control regions of the alcohol dehydrogenase promoter responsible for temporal regulation. The activity of a trans-acting protein correlates with the profile of alcohol dehydrogenase expression during embryogenesis.

MeSH Terms

Alcohol Dehydrogenase/genetics Animals Base Sequence Drosophila/embryology,genetics Gene Expression Regulation Promoter Regions, Genetic Transcription, Genetic

Chemicals

Alcohol Dehydrogenase

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Heberlein U

Howard Hughes Medical Institute, Department of Biochemistry, University of California, Berkeley 94720.

Tjian R

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/331410a0

Published

1988-02-04

Pages

410-5

Language

English

Region

England

NLM ID

0410462

Subset

External Links

PubMed source DOI: 10.1038/331410a0 View journal details

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Temporal pattern of alcohol dehydrogenase gene transcription reproduced by Drosophila stage-specific embryonic extracts.

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