Identification of a novel TNRC18-RARA fusion in acute promyelocytic leukemia lacking t(15;17)(q24;q12)/PML-RARA.

Molecular carcinogenesis ·Vol. 60 ·No. 2 ·2021-00-00

Wang Z, Wen L, Zhang L, Xu X, Chen X, Yao L, Wang M, Shen Z, Mo G, Wang Y, Zhao D, Cai W, Shen J, Chi X, Xu Y, Zeng Z, Pan J, Ruan C, Wu D, Jia Z, Chen S

Abstract

Acute promyelocytic leukemia (APL) is a unique disease entity in acute myeloid leukemia, characterized by PML-RARA fusion gene, which is generated by chromosomal translocation t(15;17)(q24;q21). We identified TNRC18-RARA as novel RARA fusion in resembling APL. Our study highlights the importance of combining multiple molecular techniques to characterize and optimally manage APL lacking classic t(15;17)(q24;q12)/PML-RARA fusion.

Keywords

PML-RARA RARA TNRC18 acute promyelocytic leukemia

MeSH 主题词

Chromosomes, Human, Pair 15/genetics Chromosomes, Human, Pair 17/genetics Gene Expression Regulation, Leukemic Humans In Situ Hybridization, Fluorescence Intracellular Signaling Peptides and Proteins/genetics,metabolism Leukemia, Promyelocytic, Acute/genetics,metabolism,pathology Male Middle Aged Oncogene Proteins, Fusion/genetics,metabolism Retinoic Acid Receptor alpha/genetics,metabolism Translocation, Genetic

Article Info

Journal

Molecular carcinogenesis

Abbr.

Mol Carcinog

ISSN

1098-2744

DOI

10.1002/mc.23276

Published

2021-00-00

Language

English

Country/Region

United States

NLM ID

8811105

External Links

PubMed source DOI: 10.1002/mc.23276 View journal details

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Identification of a novel TNRC18-RARA fusion in acute promyelocytic leukemia lacking t(15;17)(q24;q12)/PML-RARA.

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