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PMID: 3342881 Published · ppublish English Journal Article

Complementary addressed modification of double-stranded DNA within a ternary complex.

FEBS letters ·Vol. 228 ·No. 2 ·1988-02-15 ·Pages 273-6

Fedorova OS, Knorre DG, Podust LM, Zarytova VF

Abstract

Double-stranded DNA containing a d(pG)18.d(pC)18 sequence was shown to be selectively alkylated in the vicinity of this fragment using the 5'-p-(N-2-chloroethyl-N-methylamino)benzylamide of deoxyribooligocytidylate, CIRCH2NH(pdC)n (n = 9,15), in conditions favouring triple-stranded complex formation.

MeSH Terms
Alkylation Base Sequence DNA Hydrogen-Ion Concentration Molecular Sequence Data Mustard Compounds Piperidines Poly C Polydeoxyribonucleotides
Chemicals
Mustard Compounds Piperidines Polydeoxyribonucleotides poly(dG).poly(dC) poly(dC) Poly C 4(N)-(2-chloroethyl-N-methylamino)benzylamine piperidine DNA
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Fedorova O S
Institute of Bioorganic Chemistry, Siberian Division of the USSR Academy of Sciences, Novosibirsk.
Knorre D G
Podust L M
Zarytova V F
Article Info
Journal
FEBS letters
Abbr.
FEBS Lett
ISSN
0014-5793
DOI
10.1016/0014-5793(88)80014-0
Published
1988-02-15
Pages
273-6
Language
English
Region
England
NLM ID
0155157
Subset
IM
External Links
PubMed source DOI: 10.1016/0014-5793(88)80014-0 View journal details
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