Retrospective study of prognostic importance of DNA flow cytometry of urinary bladder carcinoma.

Journal of clinical pathology ·Vol. 41 ·No. 1 ·1988-01-00 ·Pages 21-5

Blomjous CE, Schipper NW, Baak JP, van Galen EM, de Voogt HJ, Meyer CJ

Abstract

Cellular DNA content was determined by flow cytometry on routinely processed paraffin sections of 61 primary and untreated transitional cell carcinomas of the urinary bladder, and correlated with tumour grade and stage and clinical follow up. All 16 (25%) grade 1 carcinomas were diploid and all 11 (20%) grade 3 tumours were aneuploid. The 34 (55%) grade 2 carcinomas comprised 13 (40%) diploid and 21 (60%) aneuploid cases. Among the 37 superficial carcinomas (stage Ta and T1), 25 (65%) were diploid; 20 (85%) of the 24 advanced tumours (stage T2 to T4) had aneuploid tracings. Ploidy was a significant prognostic indicator (p: 0.006) of five year survival. The initial presence of aneuploidy in superficial bladder carcinoma (stage Ta and T1) is a strong argument for more aggressive treatment than is customary.

MeSH Terms

Aged Aged, 80 and over Carcinoma, Transitional Cell/analysis DNA, Neoplasm/analysis Female Flow Cytometry Humans Male Middle Aged Neoplasm Staging Prognosis Recurrence Retrospective Studies Urinary Bladder Neoplasms/analysis,pathology

Chemicals

DNA, Neoplasm

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Blomjous C E

Department of Pathology, Free University Hospital, Amsterdam, The Netherlands.

Schipper N W

Baak J P

van Galen E M

de Voogt H J

Meyer C J

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Article Info

Journal

Journal of clinical pathology

Abbr.

J Clin Pathol

ISSN

0021-9746

DOI

10.1136/jcp.41.1.21

Published

1988-01-00

Pages

21-5

Language

English

Region

England

NLM ID

0376601

PMCID

PMC1141329

Subset

External Links

PubMed source DOI: 10.1136/jcp.41.1.21 PMC Full Text View journal details

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Retrospective study of prognostic importance of DNA flow cytometry of urinary bladder carcinoma.

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