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PMID: 33436678 Published · epublish English Case Reports Journal Article Research Support, Non-U.S. Gov't

Novel CFD modeling approaches to assessing urine flow in prostatic urethra after transurethral surgery.

Scientific reports ·Vol. 11 ·No. 1 ·2021-00-12 ·页码 663

Zhang B, Liu S, Liu Y, Wu B, Zhang X, Wang X, Liang X, Cao X, Wang D, Wu CL

Abstract

Assessment of the pressure and velocity of urine flow for different diameter ratios of prostatic urethra (RPU) after transurethral surgery using computational fluid dynamics (CFD). A standardized and idealized two-dimensional CFD model after transurethral surgery (CATS-1st) was developed for post-surgery mid-voiding. Using CATS-1st, 210 examples were amplified according to an array of size [3][5][14], which contained three groups of longitudinal diameters of prostatic urethra (LD-PU). Each of these groups contained five subgroups of transverse diameters of the bladder neck (TD-BN), each with 14 examples of transverse diameters of PU (TD-PU). The pressure and velocity of urine flow were monitored through flow dynamics simulation, and the relationship among RPU-1 (TD-PU/TD-BN), RPU-2 (RPU-1/LD-PU), the transverse diameter of the vortex, and the midpoint velocity of the external urethral orifice (MV-EUO) was determined. A total of 210 CATS examples, including CATS-1st examples, were analyzed. High (bladder and PU) and medium/low (the rest of the urethra) pressure zones, and low (bladder), medium (PU), and high (the rest of the urethra) velocity zones were determined. The rapid changes in the velocity were concentrated in and around the PU. Laminar flow was present in all the examples. The vortices appeared and then gradually shrank with reducing RPU on both the sides of PU in 182 examples. In the vortex examples, minimum RPU-1 and RPU-2 reached close to the values of 0.79 and 0.02, respectively. MV-EUO increased gradually with decreasing RPU. In comparison to the vortex examples, the non-vortex examples exhibited a significantly higher (p < 0.01) MV-EUO. The developed CFD models (CATS) presented an effective simulation of urine flow behavior within the PU after transurethral surgery for benign prostatic hyperplasia (BPH). These models could prove to be useful for morphological repair in PU after transurethral surgery.

MeSH 主题词
Aged Computer Simulation Humans Hydrodynamics Male Prostate/physiopathology,surgery Prostatic Hyperplasia/physiopathology,surgery Urethra/physiopathology,surgery Urination/physiology
作者与单位
共 10 位作者,点击展开单位 / ORCID
Zhang Bin
Department of Urology, First Hospital of Shanxi Medical University, Taiyuan, 030001, Shanxi, China. | Department of Urology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
Liu Shuang
Department of Urology, First Hospital of Shanxi Medical University, Taiyuan, 030001, Shanxi, China.
Liu Yinxia
Department of Obstetrics and Gynecology, Shanxi Health Vocational College, Shanxi Traditional Chinese Medicine School, Jinzhong, 030600, Shanxi, China.
Wu Bo
Department of Urology, First Hospital of Shanxi Medical University, Taiyuan, 030001, Shanxi, China.
Zhang Xuhui
Department of Urology, First Hospital of Shanxi Medical University, Taiyuan, 030001, Shanxi, China.
Wang Xin
Department of Urology, First Hospital of Shanxi Medical University, Taiyuan, 030001, Shanxi, China.
Liang Xuezhi
Department of Urology, First Hospital of Shanxi Medical University, Taiyuan, 030001, Shanxi, China.
Cao Xiaoming
Department of Urology, First Hospital of Shanxi Medical University, Taiyuan, 030001, Shanxi, China.
Wang Dongwen
National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 113 Baohe road, Longgang district, Shenzhen, 518116, China. [email protected]. | First College of Clinical Medicine, Shanxi Medical University, Taiyuan, 030001, Shanxi, China. [email protected].
Wu Chin-Lee
Department of Urology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA. | Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
Article Info
Journal
Scientific reports
Abbr.
Sci Rep
ISSN
2045-2322
Corresponding email
Published
2021-00-12
电子出版
2021-00-12
页码
663
Language
English
Country/Region
England
NLM ID
101563288
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