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PMID: 3350119 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Endogenous inhibitor of ecdysone synthesis in crabs.

Experientia ·Vol. 44 ·No. 1 ·1988-01-15 ·Pages 50-2

Naya Y, Kishida K, Sugiyama M, Murata M, Miki W, Ohnishi M, Nakanishi K

Abstract

Attempts to isolate the molt-inhibiting hormone (MIH) of crustaceans from crab eyestalks (ES) resulted in the characterization of xanthurenic acid as an inhibitor of ecdysone biosynthesis in the cultured Y-organ-complex (YOC) homogenate. It was also found that 3-hydroxy-L-kynurenine present in the ES is transformed into xanthurenic acid in the YOC and body fluid. Its mode of inhibitory action in ecdysone biosynthesis is probably inactivation of cytochrome P-450.

MeSH Terms
Animals Brachyura/metabolism Chromatography, High Pressure Liquid Culture Techniques Ecdysone/antagonists & inhibitors,biosynthesis Eye/analysis Gas Chromatography-Mass Spectrometry Invertebrate Hormones/isolation & purification Kynurenine/analogs & derivatives,isolation & purification,metabolism Xanthurenates/isolation & purification,metabolism,pharmacology
Chemicals
Invertebrate Hormones Xanthurenates molt-inhibiting hormone 3-hydroxykynurenine Kynurenine Ecdysone xanthurenic acid
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Naya Y
Suntory Institute for Bioorganic Research, Osaka, Japan.
Kishida K
Sugiyama M
Murata M
Miki W
Ohnishi M
Nakanishi K
References (9)
9 references, click to expand
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    Peptides. 1985 Jul-Aug;6(4):635-40 PMID: 2999730
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Article Info
Journal
Experientia
Abbr.
Experientia
ISSN
0014-4754
DOI
10.1007/BF01960242
Published
1988-01-15
Pages
50-2
Language
English
Region
Switzerland
NLM ID
0376547
Subset
IM
Grants
NIAID NIH HHS · AI 10187 · United States
External Links
PubMed source DOI: 10.1007/BF01960242
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