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PMID: 3353385 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Long-term memory in Aplysia modulates the total number of varicosities of single identified sensory neurons.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 85 ·No. 7 ·1988-04-00 ·Pages 2373-7

Bailey CH, Chen M

Abstract

The morphological consequences of long-term habituation and sensitization of the gill withdrawal reflex in Aplysia california were explored by examining the total number of presynaptic varicosities of single identified sensory neurons (a critical site of plasticity for the biochemical and biophysical changes that underlie both types of learning) in control and behaviorally trained animals. Sensory neurons from habituated animals had 35% fewer synaptic varicosities than did sensory neurons from control animals. In contrast, sensory neurons from sensitized animals had twice as many varicosities per sensory neuron compared to controls, as well as enlarged neuropil arbors. These changes suggest that modulation of synapse number may play a role in the maintenance of long-term memory.

MeSH Terms
Animals Aplysia/physiology Memory/physiology Neuronal Plasticity Neurons/ultrastructure Reflex/physiology
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Bailey C H
Center for Neurobiology and Behavior, New York State Psychiatric Institute, New York, NY 10032.
Chen M
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25 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.85.7.2373
Published
1988-04-00
Pages
2373-7
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC279995
Subset
IM
Grants
NIGMS NIH HHS · GM23540 · United States
NIMH NIH HHS · MH37134 · United States
External Links
PubMed source DOI: 10.1073/pnas.85.7.2373 PMC Full Text View journal details
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