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PMID: 33743394 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

A computational study of the hemodynamics of bioprosthetic aortic valves with reduced leaflet motion.

Journal of biomechanics ·Vol. 120 ·2021-00-07 ·Pages 110350

Bailoor S, Seo JH, Dasi LP, Schena S, Mittal R

Abstract

We employ a reduced degree-of-freedom aortic valve model to investigate the flow physics associated with early-stage reduced leaflet motion in bioprosthetic aortic valves. The model is coupled with a sharp-interface immersed boundary based incompressible flow solver to efficiently simulate the fluid-structure interaction. A total of 19 cases of flow through aortic valves with varying degrees of reduced leaflet motion (RLM) are considered. The characteristics of the aortic jet and the consequent aorta wall loading patterns are analyzed. Our results show that asymmetric RLM tilts the aortic jet and leads to large reverse and recirculating flow regions downstream from leaflets with restricted mobility. The changes in flow patterns increase wall pressure and shear stress fluctuations, and result in asymmetric oscillating shear on the aorta wall. These findings have implications for auscultation based diagnosis of this condition as well as the health of the aorta.

Keywords
Fluid structure interaction Immersed boundary method Leaflet thrombosis Reduced-order models Transcatheter aortic valves
MeSH Terms
Aorta Aortic Valve/surgery Bioprosthesis Heart Valve Prosthesis Hemodynamics Models, Cardiovascular Transcatheter Aortic Valve Replacement
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Bailoor Shantanu
Johns Hopkins University, Baltimore, MD, USA.
Seo Jung-Hee
Johns Hopkins University, Baltimore, MD, USA.
Dasi Lakshmi Prasad
Georgia Institute of Technology, Atlanta, GA, USA.
Schena Stefano
Johns Hopkins Medical Institute, Baltimore, MD, USA.
Mittal Rajat
Johns Hopkins University, Baltimore, MD, USA. Electronic address: [email protected].
Conflict of Interest

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Article Info
Journal
Journal of biomechanics
Abbr.
J Biomech
ISSN
1873-2380
Published
2021-00-07
Epub
2021-00-06
Pages
110350
Language
English
Region
United States
NLM ID
0157375
Subset
IM
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