Penicillins activate autolysins extracted from both Escherichia coli and Klebsiella pneumoniae envelopes.

Antimicrobial agents and chemotherapy ·Vol. 12 ·No. 6 ·1977-12-00 ·Pages 745-7

Fontana R, Satta G, Romanzi CA

Abstract

Ampicillin at a 50-mug/ml concentration effects a doubling of the autolysis rate of cell envelopes isolated from Klebsiella pneumoniae Mir A12. This antibiotic increases also by two- to threefold the depolymerizing activity of both K. pneumoniae and Escherichia coli crude extracts on a labeled peptidoglycan-lipoprotein complex. Several other penicillins also activate autolysins.

MeSH Terms

Bacteriolysis/drug effects Enzyme Activation Escherichia coli/enzymology Klebsiella pneumoniae/enzymology Penicillins/pharmacology

Chemicals

Penicillins

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Fontana R

Satta G

Romanzi C A

References (10)

10 references, click to expand

Evidence for a role of N-acetylmuramyl-L-alanine amidase in septum separation in Escherichia coli.
J Bacteriol. 1976 Nov;128(2):580-6 PMID: 61961
Murein hydrolases in the envelope of Escherichia coli. Properties in situ and solubilization from the envelope.
Eur J Biochem. 1974 Jan 3;41(1):203-8 PMID: 4205935
Sensitivity to ampicillin and cephalothin of enzymes involved in wall peptide crosslinking in Escherichia coli K12, strain 44.
Eur J Biochem. 1974 Feb 1;41(3):457-63 PMID: 4593965
Mechanism of action and development of resistance to a new amidino penicillin.
J Bacteriol. 1974 Feb;117(2):578-87 PMID: 4590478
Cell division, macromolecular synthesis and morphology dependent on the state of the envelope in a mutant of Klebsiella pneumoniae.
J Gen Microbiol. 1974 Jan;80(1):65-75 PMID: 4595009
Characterization of a conditional mutant with altered envelope showing pH-dependent morphology and temperature-dependent division.
J Gen Microbiol. 1974 Jan;80(1):51-63 PMID: 4595008
FL-1060: a new penicillin with a unique mode of action.
Biochem Biophys Res Commun. 1973 Apr 16;51(4):863-8 PMID: 4574155
Inhibition of bacterial wall lysins by lipoteichoic acids and related compounds.
Biochem Biophys Res Commun. 1975 Dec 1;67(3):1128-35 PMID: 1027
Mechanism of action of penicillin: triggering of the pneumococcal autolytic enzyme by inhibitors of cell wall synthesis.
Proc Natl Acad Sci U S A. 1975 Oct;72(10):4162-6 PMID: 674
Targets of penicillin action in Escherichia coli.
Nature. 1972 Feb 25;235(5339):426-9 PMID: 4553687

Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.12.6.745

Published

1977-12-00

Pages

745-7

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC430015

Subset

External Links

PubMed source DOI: 10.1128/AAC.12.6.745 PMC Full Text View journal details

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Penicillins activate autolysins extracted from both Escherichia coli and Klebsiella pneumoniae envelopes.

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