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PMID: 3388044 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Vasopressin mRNA in the suprachiasmatic nuclei: daily regulation of polyadenylate tail length.

Science (New York, N.Y.) ·Vol. 241 ·No. 4863 ·1988-07-15 ·Pages 342-4

Robinson BG, Frim DM, Schwartz WJ, Majzoub JA

Abstract

Daily variation has been found in the length of the polyadenylate tail attached to vasopressin messenger RNA in the suprachiasmatic nuclei, which is the location of an endogenous circadian pacemaker in mammals. No such variation was found in the supraoptic or paraventricular nuclei. This variation in the length of the polyadenylate tail may underlie the circadian rhythm of vasopressin peptide levels in cerebrospinal fluid and is a unique example of a daily rhythm in messenger RNA structure.

MeSH Terms

Animals Arginine Vasopressin/physiology Biological Clocks Circadian Rhythm Gene Expression Regulation Poly A/physiology RNA, Messenger/physiology Rats Suprachiasmatic Nucleus/physiology

Chemicals

RNA, Messenger Arginine Vasopressin Poly A

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Robinson B G

Howard Hughes Medical Institute, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.

Frim D M

Schwartz W J

Majzoub J A

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.3388044

Published

1988-07-15

Pages

342-4

Language

English

Region

United States

NLM ID

0404511

Subset

Grants

NHLBI NIH HHS · 1P50HL36568 · United States

NINDS NIH HHS · R01NS24542 · United States

External Links

PubMed source DOI: 10.1126/science.3388044 View journal details

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Vasopressin mRNA in the suprachiasmatic nuclei: daily regulation of polyadenylate tail length.

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