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PMID: 33902 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Longitudinal study of experimentally induced periodontal disease in Macaca arctoides: relationship between microflora and alveolar bone loss.

Infection and immunity ·Vol. 23 ·No. 2 ·1979-02-00 ·Pages 260-9

Slots J, Hausmann E

Abstract

Macaca arctoides monkeys develop periodontal disease, and they harbor a periodontopathic indigenous flora largely similar to that of humans. This study showed that various Haemophilus isolates and H2O2-splitting asaccharolytic Bacteroides melaninogenicus strains constituted major segments of the monkey periodontal microflora. These organisms have not been previously identified among human isolates. Furthermore, the present data revealed that asaccharolytic B. melaninogenicus strains increased in proportion from a few percent to about 66% of the total isolates concomitant with the development of a significant loss of alveolar bone mass. Hence, this study strongly implicates B. melaninogenicus subsp. asaccharolyticus and closely related strains as important pathogens in actively destructive periodontal disease.

MeSH Terms
Alveolar Process Animals Bacteria/growth & development Bacteroides/growth & development Bone Resorption/microbiology Female Haemophilus/growth & development Haplorhini Hydrogen Peroxide/metabolism Longitudinal Studies Macaca Osteolysis/complications,microbiology Periodontal Pocket/complications,microbiology Periodontitis/microbiology Prevotella melaninogenica/growth & development
Chemicals
Hydrogen Peroxide
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Slots J
Hausmann E
References (21)
21 references, click to expand
  1. Diphenylhydantoin gingival hyperplasia in Macaca arctoides: prevention by inhibition of dental plaque deposition.
    J Periodontol. 1978 Jun;49(6):310-25 PMID: 100589
  2. Blastogenic response of human lymphocytes to oral bacterial antigens: comparison of individuals with periodontal disease to normal and edentulous subjects.
    Infect Immun. 1976 Nov;14(5):1213-20 PMID: 10259
  3. Structure of the microbial flora associated with periodontal health and disease in man. A light and electron microscopic study.
    J Periodontol. 1976 Jan;47(1):1-18 PMID: 1063849
  4. PERIODONTAL DISEASE IN PREGNANCY. I. PREVALENCE AND SEVERITY.
    Acta Odontol Scand. 1963 Dec;21:533-51 PMID: 14121956
  5. PERIODONTAL DISEASE IN PREGNANCY. II. CORRELATION BETWEEN ORAL HYGIENE AND PERIODONTAL CONDTION.
    Acta Odontol Scand. 1964 Feb;22:121-35 PMID: 14158464
  6. Lymphocyte blastogenesis to plaque antigens in human periodontal disease. I. Populations of varying severity of disease.
    J Periodontal Res. 1977 Jul;12(4):298-309 PMID: 142139
  7. REQUIRED ROLE OF BACTEROIDES MELANINOGENICUS IN MIXED ANAEROBIC INFECTIONS.
    J Infect Dis. 1965 Jun;115:247-53 PMID: 14331707
  8. Attachment of Bacteroides melaninogenicus subsp. asaccharolyticus to oral surfaces and its possible role in colonization of the mouth and of periodontal pockets.
    Infect Immun. 1978 Jan;19(1):254-64 PMID: 24002
  9. Microbiota of gingivitis in man.
    Scand J Dent Res. 1978 May;86(3):174-81 PMID: 276916
  10. The predominant cultivable microflora of advanced periodontitis.
    Scand J Dent Res. 1977 Jan-Feb;85(2):114-21 PMID: 320648
  11. Microbiology of periodontal disease -- present status and future considerations.
    J Periodontol. 1977 Sep;48(9):497-504 PMID: 333085
  12. Effect of ligature placement and dental plaque on periodontal tissue breakdown in the dog.
    J Periodontol. 1978 Jul;49(7):343-50 PMID: 359775
  13. Diphenylhydantoin gingival hyperplasia in Macaca arctoides: a new human model.
    J Periodontol. 1977 Jun;48(6):325-36 PMID: 405470
  14. Experimental gingivitis in Macaca speciosa monkeys: clinical, bacteriologic and histologic similarities to human gingivitis.
    J Periodontol. 1973 Aug;44(8):454-63 PMID: 4198722
  15. Quantitative long-term determinations of the alveolar bone mineral mass in man by 125I absorptiometry. I. Accuracy and precision of the method.
    Acta Radiol Ther Phys Biol. 1974 Oct;13(5):377-92 PMID: 4462363
  16. Experimental marginal periodontitis in squirrel monkeys.
    J Periodontol. 1973 Mar;44(3):140-4 PMID: 4631609
  17. Endotoxin: stimulation of bone resorption in tissue culture.
    Science. 1970 May 15;168(3933):862-4 PMID: 4910373
  18. Inhibition of phagocytosis in vitro by obligate anaerobes.
    Lancet. 1977 Dec 17;2(8051):1252-4 PMID: 73952
  19. Pathogenesis of inflammatory periodontal disease. A summary of current work.
    Lab Invest. 1976 Mar;34(3):235-49 PMID: 765622
  20. A taxonomic study of the genus Haemophilus, with the proposal of a new species.
    J Gen Microbiol. 1976 Mar;93(1):9-62 PMID: 772168
  21. Conversion of chronic gingivitis to periodontitis in squirrel monkeys.
    J Periodontol. 1976 Dec;47(12):710-6 PMID: 825632
Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.23.2.260-269.1979
Published
1979-02-00
Pages
260-9
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC414158
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.23.2.260-269.1979 PMC Full Text View journal details
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