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PMID: 33911166 Published · epublish English Journal Article Research Support, Non-U.S. Gov't

Untargeted metabolomic analysis in cats with naturally occurring inflammatory bowel disease and alimentary small cell lymphoma.

Scientific reports ·Vol. 11 ·No. 1 ·2021-00-28 ·页码 9198

Marsilio S, Chow B, Hill SL, Ackermann MR, Estep JS, Sarawichitr B, Pilla R, Lidbury JA, Steiner JM, Suchodolski JS

Abstract

Feline chronic enteropathy (CE) is a common gastrointestinal disorder in cats and mainly comprises inflammatory bowel disease (IBD) and small cell lymphoma (SCL). Differentiation between IBD and SCL can be diagnostically challenging. We characterized the fecal metabolome of 14 healthy cats and 22 cats with naturally occurring CE (11 cats with IBD and 11 cats with SCL). Principal component analysis and heat map analysis showed distinct clustering between cats with CE and healthy controls. Random forest classification revealed good group prediction for healthy cats and cats with CE, with an overall out-of-bag error rate of 16.7%. Univariate analysis indicated that levels of 84 compounds in cats with CE differed from those in healthy cats. Polyunsaturated fatty acids held discriminatory power in differentiating IBD from SCL. Metabolomic profiles of cats with CE resembled those in people with CE with significant alterations of metabolites related to tryptophan, arachidonic acid, and glutathione pathways.

MeSH 主题词

Animals Cat Diseases/diagnosis,etiology,metabolism Cats Diagnosis, Differential Female Inflammatory Bowel Diseases/diagnosis,etiology,metabolism,veterinary Lymphoma/diagnosis,etiology,metabolism,veterinary Male Metabolome

作者与单位

共 10 位作者，点击展开单位 / ORCID

Marsilio Sina ORCID

Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, One Shields Avenue, Davis, CA, 95616, USA. [email protected]. | Gastrointestinal Laboratory, Texas A&M University, College Station, TX, USA. [email protected].

Chow Betty

Veterinary Specialty Hospital, San Diego, CA, USA. | VCA Animal Specialty and Emergency Center, Los Angeles, CA, USA.

Hill Steve L

Veterinary Specialty Hospital, San Diego, CA, USA. | Flagstaff Veterinary Internal Medicine Consulting, Flagstaff, AZ, USA.

Ackermann Mark R

Oregon Veterinary Diagnostic Laboratory, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR, USA.

Estep J Scot

Texas Veterinary Pathology, LLC., San Antonio, TX, USA.

Sarawichitr Benjamin