Questioning of reported evidence for guanosine tetraphosphate synthesis in a ribosome system from mouse embryos.

Cell ·Vol. 12 ·No. 4 ·1977-12-00 ·Pages 1127-31

Martini O, Irr J, Richter D

Abstract

In 1974, Irr, Kaulenas and Unsworth reported that ppGpp is synthesized by cytosolic ribosomes from mouse embryos and proposed a role for ppGpp in the process of differentiation. This proposal is being challenged because ribosomes of mouse embryos from various stages of development and of mouse embryoid bodies were completely inactive in ppGpp formation.

MeSH Terms

Animals Embryo, Mammalian/metabolism Escherichia coli/metabolism Gestational Age Guanine Nucleotides/biosynthesis Guanosine Tetraphosphate/biosynthesis Membranes/metabolism Mice Ribosomes/metabolism

Chemicals

Guanine Nucleotides Guanosine Tetraphosphate

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Martini O

Irr J

Richter D

Article Info

Journal

Cell

Abbr.

Cell

ISSN

0092-8674

DOI

10.1016/0092-8674(77)90175-1

Published

1977-12-00

Pages

1127-31

Language

English

Region

United States

NLM ID

0413066

Subset

External Links

PubMed source DOI: 10.1016/0092-8674(77)90175-1 View journal details

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Questioning of reported evidence for guanosine tetraphosphate synthesis in a ribosome system from mouse embryos.

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