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PMID: 3413113 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

A large family of bacterial activator proteins.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 85 ·No. 18 ·1988-09-00 ·Pages 6602-6

Henikoff S, Haughn GW, Calvo JM, Wallace JC

Abstract

At least nine different bacterial proteins belong to the LysR family. The gene sequence for one of these proteins is presented here. Six others (Escherichia coli LysR, IlvY, CysB; Salmonella typhimurium MetR; Rhizobium NodD; and Enterobacter cloacae AmpR) are known to activate other genes. Based on sequence alignments, each member of this family is predicted to have a helix-turn-helix DNA binding motif near its amino terminus. The combined evidence indicates that all nine proteins are related by common ancestry, are similarly folded, and are not detectably related to other known bacterial regulatory proteins. The DNA database searching procedure and other methods used in this study should be useful in detecting other groups of related proteins.

MeSH Terms
Bacterial Proteins/analysis,genetics Base Sequence DNA, Bacterial/analysis,metabolism Enterobacteriaceae/analysis Information Systems Molecular Sequence Data
Chemicals
Bacterial Proteins DNA, Bacterial
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Henikoff S
Fred Hutchinson Cancer Research Center, Seattle, WA 98104.
Haughn G W
Calvo J M
Wallace J C
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.85.18.6602
Published
1988-09-00
Pages
6602-6
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC282025
Subset
IM
Grants
NIGMS NIH HHS · GM29009 · United States
Databases
GENBANK
J03862, M21150
External Links
PubMed source DOI: 10.1073/pnas.85.18.6602 PMC Full Text View journal details
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