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PMID: 3417356 Published · ppublish English Journal Article

Effect of the gastrointestinal microflora on induction and maintenance of oral tolerance to ovalbumin in C3H/HeJ mice.

Infection and immunity ·Vol. 56 ·No. 10 ·1988-10-00 ·Pages 2766-8

Moreau MC, Corthier G

Abstract

The effect of the digestive microflora on oral tolerance to ovalbumin was studied by using axenic (germfree) and conventional C3H/HeJ mice. In contrast to reported results of studies with sheep erythrocytes, oral administration of ovalbumin induced tolerance in axenic mice, but the maintenance of tolerance was found to be of shorter duration than was with conventional mice. These data indicate that the contribution of the microflora to oral tolerance depends on the antigen used.

MeSH Terms
Administration, Oral Animals Germ-Free Life Immune Tolerance Intestines/immunology,microbiology Mice Mice, Inbred C3H/immunology Ovalbumin/administration & dosage,immunology Time Factors
Chemicals
Ovalbumin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Moreau M C
Laboratoire d'Ecologie Microbienne, CRJJ, INRA, Jouy-en-Josas, France.
Corthier G
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19 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.56.10.2766-2768.1988
Published
1988-10-00
Pages
2766-8
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC259643
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.56.10.2766-2768.1988 PMC Full Text View journal details
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