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PMID: 342401 Published · ppublish English Journal Article

Differential tolerance of thymus-independent and thymus-dependent antibody responses.

Immunology ·Vol. 34 ·No. 2 ·1978-02-00 ·Pages 337-45

Tite JP, Marshall-Clarke S, Playfair JH

Abstract

The effect of pre-immunization with soluble haptenated serum proteins or haptenated carbohydrates on the subsequent responses to the hapten in thymus-dependent or thymus-independent form was investigated. In certain cases both thymus-dependent and -independent responses were suppressed whilst in others a differential suppression of thymus-independent responsiveness was observed. These results are discussed in terms of B-cell subpopulations and mechanisms of tolerance induction.

MeSH Terms
Animals Antibody Formation B-Lymphocytes/immunology Blood Proteins/immunology Carbohydrates/immunology Dinitrobenzenes/immunology Female Haptens Hemolytic Plaque Technique Immunosuppression Therapy Lymphocyte Cooperation Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred CBA Mice, Nude Spleen/cytology T-Lymphocytes/immunology
Chemicals
Blood Proteins Carbohydrates Dinitrobenzenes Haptens
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Tite J P
Marshall-Clarke S
Playfair J H
References (21)
21 references, click to expand
  1. Role of epitope density in the induction of tolerance and immunity with thymus-independent antigens. III. Interaction of epitope density and receptor avidity.
    Eur J Immunol. 1976 Sep;6(9):646-50 PMID: 63380
  2. Mechanisms by which hapten conjugates of pneumococcal polysaccharide interfere with the challenge of anti-hapten memory cells.
    Eur J Immunol. 1976 Jun;6(6):434-42 PMID: 11101
  3. B cell tolerance induced by polymeric antigens. II. Effects of tolerance on hapten-binding lymphocyte levels in primary and secondary antibody responses.
    Eur J Immunol. 1976 Jun;5(6):366-72 PMID: 10168
  4. B cell tolerance induced by polymeric antigens. I. Comparison of the dose and epitope density requirements for inactivation of primed and unprimed B cells in vivo.
    Eur J Immunol. 1976 Jun;5(6):361-5 PMID: 10167
  5. In vitro responses of CBA/N mice: spleen cells of mice with an X-linked defect that precludes immune responses to several thymus-independent antigens can respond to TNP-lipopolysaccharide.
    J Immunol. 1976 Oct;117(4):1363-9 PMID: 789772
  6. Evidence for separate subpopulations of B cells responding to T-independent and T-dependent immunogens.
    J Immunol. 1976 Nov;117(5 Pt.2):1749-52 PMID: 1086861
  7. Cellular requirements for the primary in vitro antibody response to DNP-ficoll.
    J Exp Med. 1974 May 1;139(5):1354-60 PMID: 4596514
  8. Separate thymus dependent and thymus independent antibody forming cell precursors.
    Nat New Biol. 1971 Jun 2;231(22):149-51 PMID: 5283017
  9. Overlap stimulation of primary and secondary B cells by cross-reacting determinants.
    J Exp Med. 1973 Nov 1;138(5):1276-81 PMID: 4126771
  10. The relationship between antigenic structure and the requirement for thymus-derived cells in the immune response.
    J Exp Med. 1971 Jul 1;134(1):103-19 PMID: 4104294
  11. The tolerant cell: direct evidence for receptor blockade by tolerogen.
    J Immunol. 1974 May;112(5):1793-803 PMID: 4594416
  12. Separate signals for the initiation of proliferation and differentiation in the b cell response to antigen.
    Transplant Rev. 1975;23:66-77 PMID: 49107
  13. Induction of immunity and tolerance in vitro by hapten protein conjugates. I. The relationship between the degree of hapten conjugation and the immunogenicity of dinitrophenylated polymerized flagellin.
    J Exp Med. 1972 Apr 1;135(4):735-53 PMID: 5062922
  14. Mechanisms at the cellular level during induction of high zone tolerance in vitro.
    Cell Immunol. 1972 Sep;5(1):130-6 PMID: 5066499
  15. A third signal in B cell activation given by TRF.
    Transplant Rev. 1975;23:176-88 PMID: 1094630
  16. Murine B-cell subpopulations responsive to T-dependent and T-independent antigens.
    J Exp Med. 1976 Aug 1;144(2):382-97 PMID: 1085326
  17. Age-dependent changes in the relative affinity of anti-dinitrophenyl antibodies in mice.
    Immunology. 1975 Sep;29(3):477-86 PMID: 1100520
  18. Effect of azathioprine on in vitro antibody response. Differential effect on B cells involved in thymus-dependent and independent responses.
    Clin Exp Immunol. 1975 Oct;22(1):139-52 PMID: 1082392
  19. B Cell heterogeneity - difference in the size of B lymphocytes responding to T dependent and T independent antigens.
    Cell Immunol. 1975 Jul;18(1):88-97 PMID: 1079756
  20. Loss of carrier-determined tolerance in vitro with loss of receptor blockade.
    J Immunol. 1976 Jan;116(1):223-6 PMID: 1245739
  21. Chemical coupling of peptides and proteins to polysaccharides by means of cyanogen halides.
    Nature. 1967 Jun 24;214(5095):1302-4 PMID: 6056841
Article Info
Journal
Immunology
Abbr.
Immunology
ISSN
0019-2805
Published
1978-02-00
Pages
337-45
Language
English
Region
England
NLM ID
0374672
PMCID
PMC1457698
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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