Mutagenic effect of dichloromethane on Salmonella typhimurium.

Mutation research ·Vol. 56 ·No. 3 ·1978-01-00 ·Pages 245-8

Jongen WM, Alink GM, Koeman JH

Abstract

The possible mutagenicity of the organic solvent dichloromethane was investigated with the mutation test as described by Ames et al. The compound was mutagenic in both tester strains used, namely TA98 and TA100. The administration of rat-liver homogenate did not appear to be essential though it slightly increased the number of mutations.

MeSH Terms

Genetic Techniques Hydrocarbons, Chlorinated/pharmacology Methylene Chloride/pharmacology Microsomes, Liver/metabolism Mutagens Salmonella typhimurium/genetics

Chemicals

Hydrocarbons, Chlorinated Mutagens Methylene Chloride

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Jongen W M

Alink G M

Koeman J H

Article Info

Journal

Mutation research

Abbr.

Mutat Res

ISSN

0027-5107

DOI

10.1016/0027-5107(78)90191-4

Published

1978-01-00

Pages

245-8

Language

English

Region

Netherlands

NLM ID

0400763

Subset

External Links

PubMed source DOI: 10.1016/0027-5107(78)90191-4 View journal details

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Mutagenic effect of dichloromethane on Salmonella typhimurium.

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