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PMID: 3436320 Published · ppublish English Journal Article

In vitro activity of ciprofloxacin against methicillin-susceptible and methicillin-resistant staphylococci.

European journal of clinical microbiology ·Vol. 6 ·No. 5 ·1987-10-00 ·Pages 581-4

Gahrn-Hansen B, Søgaard P, Arpi M

Abstract

Ciprofloxacin was found to be active against selected strains of methicillin-resistant as well as methicillin-susceptible Staphylococcus aureus and Staphylococcus epidermidis, having minimal inhibitory concentrations less than 0.8 micrograms/ml with inocula of approximately 10(4) CFU/ml. When killing kinetic studies were done with inocula of approximately 10(6) CFU/ml and various ciprofloxacin concentrations, the killing effect was low (less than 3 log10 in 6 h) and regrowth of the culture was seen after 24 h in at least one Staphylococcus aureus strain. After 48 h incubation, mutants with MICs eightfold that of the parental strain had grown to a number of approximately 10(10) CFU/ml.

MeSH Terms
Ciprofloxacin/pharmacology Dose-Response Relationship, Drug Methicillin/pharmacology Penicillin Resistance Staphylococcus aureus/drug effects Staphylococcus epidermidis/drug effects
Chemicals
Ciprofloxacin Methicillin
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Gahrn-Hansen B
Department of Antibiotics, Statens Seruminstitut, Copenhagen S, Denmark.
Søgaard P
Arpi M
References (9)
9 references, click to expand
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Article Info
Journal
European journal of clinical microbiology
Abbr.
Eur J Clin Microbiol
ISSN
0722-2211
DOI
10.1007/BF02014254
Published
1987-10-00
Pages
581-4
Language
English
Region
Germany
NLM ID
8219582
Subset
IM
External Links
PubMed source DOI: 10.1007/BF02014254
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