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PMID: 3446192 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Graphical and statistical analysis of hyperbolic tight-binding inhibition.

The Biochemical journal ·Vol. 244 ·No. 3 ·1987-06-15 ·Pages 793-6

Baici A

Abstract

Equations are described for the analysis of enzyme-catalysed reactions in the presence of hyperbolic tight-binding inhibitors using both graphical and non-linear-regression methods. The general character of the equations allows the interpretation of several other kinetic mechanisms. As an example, the tight-binding hyperbolic non-competitive inhibition of human leucocyte elastase by a polysulphated glycosaminoglycan is analysed.

MeSH Terms

Enzyme Inhibitors Glycosaminoglycans/pharmacology Humans Kinetics Leukocytes/enzymology Models, Biological Pancreatic Elastase/antagonists & inhibitors,blood

Chemicals

Enzyme Inhibitors Glycosaminoglycans A73025 Pancreatic Elastase

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Baici A

Department of Rheumatology, University Hospital, Zurich, Switzerland.

References (16)

16 references, click to expand

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Article Info

Journal

The Biochemical journal

Abbr.

Biochem J

ISSN

0264-6021

DOI

10.1042/bj2440793

Published

1987-06-15

Pages

793-6

Language

English

Region

England

NLM ID

2984726R

PMCID

PMC1148066

Subset

External Links

PubMed source DOI: 10.1042/bj2440793 PMC Full Text View journal details

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Graphical and statistical analysis of hyperbolic tight-binding inhibition.

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