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PMID: 3458670 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

A biochemical characterization of feline MHC products: unusually high expression of class II antigens on peripheral blood lymphocytes.

Immunogenetics ·Vol. 23 ·No. 5 ·1986-00-00 ·Pages 341-7

Neefjes JJ, Hensen EJ, de Kroon TI, Ploegh HL

Abstract

The polymorphism of feline MHC antigens was examined using biochemical methods. The following observations were made: (1) feline class I and II antigens are polymorphic. Their biochemical features were established using rabbit and mouse reagents directed against human MHC products; they resemble those observed for other mammalian species; (2) the expression of class II antigens in unstimulated cat peripheral blood lymphocytes (PBLs) appears to be unusually high. Cat PBLs express far more class II than class I antigens, whereas in human Epstein-Barr virus-transformed lines, which are known to express relatively large amounts of class II antigens, the situation is reversed.

MeSH Terms
Animals Antibodies, Monoclonal Cats/immunology Detergents Histocompatibility Antigens/immunology Histocompatibility Antigens Class II/immunology Isoelectric Point Lymphocytes/immunology Major Histocompatibility Complex Membrane Proteins/analysis Molecular Weight
Chemicals
Antibodies, Monoclonal Detergents Histocompatibility Antigens Histocompatibility Antigens Class II Membrane Proteins
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Neefjes J J
Hensen E J
de Kroon T I
Ploegh H L
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Article Info
Journal
Immunogenetics
Abbr.
Immunogenetics
ISSN
0093-7711
DOI
10.1007/BF00398799
Published
1986-00-00
Pages
341-7
Language
English
Region
United States
NLM ID
0420404
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00398799 View journal details
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