Role of zinc and calcium in the formation and storage of insulin in the pancreatic beta-cell.

Cell and tissue research ·Vol. 188 ·No. 1 ·1978-03-31 ·Pages 107-18

Howell SL, Tyhurst M, Duvefelt H, Andersson A, Hellerström C

Abstract

暂无摘要

MeSH Terms

Animals Calcium/deficiency,physiology Insulin/metabolism Islets of Langerhans/metabolism,ultrastructure Male Mice Microscopy, Electron Proinsulin/biosynthesis Zinc/deficiency,physiology

Chemicals

Insulin Proinsulin Zinc Calcium

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Howell S L

Tyhurst M

Duvefelt H

Andersson A

Hellerström C

References (14)

14 references, click to expand

The significance of calcium in insulin secretion. Ultrastructural studies on identification and localization of calcium in activated and inactivated B cells of mice.
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Physicochemical characteristics of insulin secretion granules.
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Intracellular localization of calcium in pancreatic B-cells [proceedings].
Biochem Soc Trans. 1977;5(4):875-9 PMID: 334598
Patterns of calcium localization in pancreatic endocrine cells.
J Cell Sci. 1976 Jun;21(1):107-17 PMID: 819448
The electron microscopic localization of cations to pancreatic islets of Langerhans and their possible tole in insulin secretion.
J Ultrastruct Res. 1973 Feb;42(3):298-311 PMID: 4573993
Solubilizing effect of nucleotides on isolated insulin secretory granules.
J Cell Biol. 1970 Oct;47(1):289-93 PMID: 4397930
Effects of glucose concentration on incorporation of [3H]leucine into insulin using isolated mammalian islets of Langerhans.
Biochim Biophys Acta. 1966 Dec 28;130(2):519-21 PMID: 5339718
Anti-insulin serum coupled to Sepharose 4B as a tool for the investigation of insulin biosynthesis in the B-cells of obese hyperglycemic mice.
Endocrinology. 1975 Nov;97(5):1241-7 PMID: 1102296
Metabolic characteristics of isolated pancreatic islets in tissue culture.
Diabetes. 1972;21(2 Suppl):546-54 PMID: 4559919
Isolation and properties of secretory granules from rat islets of Langerhans. II. Ultrastructure of the beta granule.
J Cell Biol. 1969 Apr;41(1):162-6 PMID: 4887228
Determination of total serum insulin (IRI) in insulin-treated diabetic patients.
Diabetologia. 1972 Aug;8(4):260-6 PMID: 4673942
Isolation and properties of secretory granules from rat islets of Langerhans. 3. Studies of the stability of the isolated beta granules.
J Cell Biol. 1969 Apr;41(1):167-76 PMID: 4887229
Calcium distribution in islets of Langerhans: a study of calcium concentrations and of calcium accumulation in B cell organelles.
J Cell Sci. 1975 Nov;19(2):395-409 PMID: 172523
Role of ATP in the intracellular translocation of proinsulin and insulin in the rat pancreatic B cell.
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Article Info

Journal

Cell and tissue research

Abbr.

Cell Tissue Res

ISSN

0302-766X

DOI

10.1007/BF00220518

Published

1978-03-31

Pages

107-18

Language

English

Region

Germany

NLM ID

0417625

Subset

External Links

PubMed source DOI: 10.1007/BF00220518 View journal details

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Role of zinc and calcium in the formation and storage of insulin in the pancreatic beta-cell.

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