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PMID: 3464007 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Evidence suggesting that the direct growth-promoting effect of growth hormone on cartilage in vivo is mediated by local production of somatomedin.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 83 ·No. 20 ·1986-10-00 ·Pages 7932-4

Schlechter NL, Russell SM, Spencer EM, Nicoll CS

Abstract

We have used a catheterization system that permits chronic infusion into the arterial supply of one hindlimb of rats to study the direct effects of rat growth hormone and human somatomedin C on growth of the tibial epiphyseal cartilage plate in hypophysectomized rats. Rat growth hormone (0.4 microgram per day) or human somatomedin C (0.25, 1, or 4 micrograms per day) stimulated growth of the epiphyseal plate of the infused limb but not of that of the contralateral noninfused limb. The somatomedin C had a dose-related effect. Rabbit antiserum to human somatomedin C, but not normal rabbit serum, completely abolished the direct growth effect of the rat growth hormone when it was co-infused with the hormone. These results support the concept that growth hormone stimulates long bone growth by inducing local production of somatomedin, which in turn stimulates cell proliferation in an autocrine or paracrine fashion. However, they do not exclude the possibility that serum somatomedin may also play a role.

MeSH Terms
Animals Cartilage/drug effects,growth & development Growth Hormone/pharmacology Insulin-Like Growth Factor I/pharmacology Male Rats Somatomedins/biosynthesis
Chemicals
Somatomedins Insulin-Like Growth Factor I Growth Hormone
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Schlechter N L
Russell S M
Spencer E M
Nicoll C S
References (33)
33 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.83.20.7932
Published
1986-10-00
Pages
7932-4
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC386837
Subset
IM
Grants
NIADDK NIH HHS · AM-28098 · United States
NIADDK NIH HHS · AM-35496 · United States
NICHD NIH HHS · HD-14661 · United States
External Links
PubMed source DOI: 10.1073/pnas.83.20.7932 PMC Full Text View journal details
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