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PMID: 3466790 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Induction of anti-HIV neutralizing antibodies by synthetic peptides.

The EMBO journal ·Vol. 5 ·No. 11 ·1986-11-00 ·Pages 3065-71

Chanh TC, Dreesman GR, Kanda P, Linette GP, Sparrow JT, Ho DD, Kennedy RC

Abstract

Two synthetic peptides containing amino acid sequences analogous to the envelope glycoprotein of human T-lymphotropic virus (HTLV) type III (HTLV-III) and lymphadenopathy associated virus (LAV) were produced and used to immunize rabbits. The subsequent rabbit antisera neutralized HTLV-III infectivity in vitro. The two synthetic peptides corresponded to regions associated with the gp120 or gp41 subunits respectively, of human immunodeficiency virus (HIV). This data indicates that at least two neutralizing epitopes are present on the envelope glycoprotein of HIV and these epitopes are associated with two distinct virus envelope glycoproteins. Antisera generated against these peptides neutralized infectivity of two different isolates of HTLV-III. The data is discussed in terms of possible strategy for developing an effective vaccine against the etiologic agents of acquired immune deficiency syndrome (AIDS).

MeSH Terms
Amino Acid Sequence Animals Antibodies, Viral/genetics Antibody Formation DNA Replication HIV/genetics,immunology HIV Antibodies Kinetics Neutralization Tests Peptides/chemical synthesis Rabbits/immunology Virus Replication
Chemicals
Antibodies, Viral HIV Antibodies Peptides
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Chanh T C
Dreesman G R
Kanda P
Linette G P
Sparrow J T
Ho D D
Kennedy R C
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47 references, click to expand
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
Published
1986-11-00
Pages
3065-71
Language
English
Region
England
NLM ID
8208664
PMCID
PMC1167262
Subset
IM
Grants
NIAID NIH HHS · AI 22307-01 · United States
NIAID NIH HHS · AI23619-01 · United States
NHLBI NIH HHS · N01-HL-23505 · United States
External Links
PubMed source PMC Full Text View journal details
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