Localization of the Hprt locus by in situ hybridization and distribution of loci on the mouse X-chromosome.

The hypoxanthine phosphoribosyltransferase locus (Hprt) of the mouse has been localized by in situ hybridization to band XA6. Comparison of the distributions of known loci on the genetic and cytogenetic maps of the X-chromosome suggests some chiasma localization with a relatively high frequency of chiasmata in the F bands. In the A bands there appear to be fewer known loci than expected, but no evidence has been found so far of excessive chiasma formation.