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PMID: 3472222 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Human immunodeficiency virus can productively infect cultured human glial cells.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 84 ·No. 10 ·1987-05-00 ·Pages 3526-30

Cheng-Mayer C, Rutka JT, Rosenblum ML, McHugh T, Stites DP, Levy JA

Abstract

Six isolates of the human immunodeficiency virus (HIV) showed differences in their ability to productively infect glioma-derived cell lines and early-passage human brain cell cultures. Susceptibility to HIV infection correlated well with the expression of the astrocyte marker glial fibrillary acidic protein. The CD4 molecule was expressed on some, but not all, of the brain-derived cells; however, no correlation was observed between CD4 protein expression and susceptibility to virus infection. The results show that HIV can productively infect human brain cells, particularly those of glial origin, and suggest that these cell types in the brain can harbor the virus.

MeSH Terms
Antigens/analysis Brain Neoplasms/microbiology Cell Line DNA Replication Glioma/microbiology HIV/genetics,pathogenicity Humans Virulence Virus Replication
Chemicals
Antigens
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Cheng-Mayer C
Rutka J T
Rosenblum M L
McHugh T
Stites D P
Levy J A
References (30)
30 references, click to expand
  1. An acidic protein isolated from fibrous astrocytes.
    Brain Res. 1971 May 7;28(2):351-4 PMID: 5113526
  2. Lack of requirement of murine leukemia virus for early steps in infection of mouse embryo cells by murine sarcoma virus.
    Virology. 1971 Sep;45(3):844-7 PMID: 4331113
  3. The role of glial fibrillary acidic protein in the diagnosis of central nervous system tumors.
    Acta Neuropathol. 1978 Jun 30;42(3):183-90 PMID: 209658
  4. GFA and S 100 protein levels as an index for malignancy in human gliomas and neurinomas.
    J Natl Cancer Inst. 1979 Mar;62(3):479-83 PMID: 216839
  5. Heterogeneity of Genotypic and phenotypic characteristics of fifteen permanent cell lines derived from human gliomas.
    J Neuropathol Exp Neurol. 1981 May;40(3):201-29 PMID: 6260907
  6. Fluorescent phycobiliprotein conjugates for analyses of cells and molecules.
    J Cell Biol. 1982 Jun;93(3):981-6 PMID: 6749865
  7. Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS).
    Science. 1983 May 20;220(4599):868-71 PMID: 6189183
  8. Formation and growth of multicellular spheroids of human origin.
    Int J Cancer. 1983 May 15;31(5):523-33 PMID: 6852971
  9. Autopsy pathology in the acquired immune deficiency syndrome.
    Am J Pathol. 1983 Sep;112(3):357-82 PMID: 6311021
  10. Astrocytes present myelin basic protein to encephalitogenic T-cell lines.
    Nature. 1984 Jan 19-25;307(5948):273-6 PMID: 6198590
  11. Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS.
    Science. 1984 May 4;224(4648):500-3 PMID: 6200936
  12. Isolation of lymphocytopathic retroviruses from San Francisco patients with AIDS.
    Science. 1984 Aug 24;225(4664):840-2 PMID: 6206563
  13. Subacute encephalitis in acquired immune deficiency syndrome: a postmortem study.
    Am J Clin Pathol. 1984 Dec;82(6):678-82 PMID: 6095642
  14. The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus.
    Nature. 1984 Dec 20-1985 Jan 2;312(5996):763-7 PMID: 6096719
  15. T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV.
    Nature. 1984 Dec 20-1985 Jan 2;312(5996):767-8 PMID: 6083454
  16. HTLV-III infection in brains of children and adults with AIDS encephalopathy.
    Science. 1985 Jan 11;227(4683):177-82 PMID: 2981429
  17. Nucleotide sequence and expression of an AIDS-associated retrovirus (ARV-2).
    Science. 1985 Feb 1;227(4686):484-92 PMID: 2578227
  18. Neurological manifestations of the acquired immunodeficiency syndrome (AIDS): experience at UCSF and review of the literature.
    J Neurosurg. 1985 Apr;62(4):475-95 PMID: 2983051
  19. Vacuolar myelopathy pathologically resembling subacute combined degeneration in patients with the acquired immunodeficiency syndrome.
    N Engl J Med. 1985 Apr 4;312(14):874-9 PMID: 3974673
  20. Isolation of AIDS-associated retroviruses from cerebrospinal fluid and brain of patients with neurological symptoms.
    Lancet. 1985 Sep 14;2(8455):586-8 PMID: 2863599
  21. Isolation of HTLV-III from cerebrospinal fluid and neural tissues of patients with neurologic syndromes related to the acquired immunodeficiency syndrome.
    N Engl J Med. 1985 Dec 12;313(24):1493-7 PMID: 2999591
  22. Characterization of the AIDS-associated retrovirus reverse transcriptase and optimal conditions for its detection in virions.
    Virology. 1985 Dec;147(2):326-35 PMID: 2416116
  23. AIDS-associated retroviruses (ARV) can productively infect other cells besides human T helper cells.
    Virology. 1985 Dec;147(2):441-8 PMID: 2416120
  24. Binding of HTLV-III/LAV to T4+ T cells by a complex of the 110K viral protein and the T4 molecule.
    Science. 1986 Jan 24;231(4736):382-5 PMID: 3001934
  25. Differential susceptibility to the acquired immunodeficiency syndrome retrovirus in cloned cells of human leukemic T-cell line Molt-4.
    J Virol. 1986 Mar;57(3):1159-62 PMID: 2419583
  26. An ultrastructural and immunocytochemical analysis of leptomeningeal and meningioma cultures.
    J Neuropathol Exp Neurol. 1986 May;45(3):285-303 PMID: 3083053
  27. Viral particles induce Ia antigen expression on astrocytes.
    Nature. 1986 Apr 10-16;320(6062):543-6 PMID: 3008003
  28. Human immunodeficiency viruses.
    Science. 1986 May 9;232(4751):697 PMID: 3008335
  29. Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy.
    Science. 1986 Sep 5;233(4768):1089-93 PMID: 3016903
  30. Cellular localization of human immunodeficiency virus infection within the brains of acquired immune deficiency syndrome patients.
    Proc Natl Acad Sci U S A. 1986 Sep;83(18):7089-93 PMID: 3018755
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.84.10.3526
Published
1987-05-00
Pages
3526-30
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC304904
Subset
IM
Grants
NCI NIH HHS · CA09043 · United States
NCI NIH HHS · CA31882 · United States
External Links
PubMed source DOI: 10.1073/pnas.84.10.3526 PMC Full Text View journal details
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