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PMID: 3480009 Published · ppublish English Case Reports Journal Article Research Support, Non-U.S. Gov't

Philadelphia-positive chronic myelogenous leukemia with breakpoint 5' of the breakpoint cluster region but within the bcr gene.

Blut ·Vol. 55 ·No. 6 ·1987-12-00 ·Pages 505-11

Bartram CR, Bross-Bach U, Schmidt H, Waller HD

Abstract

We report on the first Philadelphia chromosome (Ph) positive chronic myelogenous leukemia (CML) characterized by a rearrangement within the 5' part of the bcr gene on chromosome 22, but outside the restricted breakpoint cluster region. In situ hybridization studies revealed a translocation of the c-abl oncogene to the Ph chromosome and Northern blot analysis identified a chimeric 8 kb bcr/abl RNA transcript in leukemic cells. These data suggest that 1. less bcr coding sequences than previously assumed may be essential for the putative transforming activity of the rearranged bcr/abl gene and 2. the bcr probes currently used for diagnostic purposes could miss Ph-positive CML cases.

MeSH Terms
Adult Humans Leukemia, Myeloid/genetics Male Oncogenes Philadelphia Chromosome
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Bartram C R
Department of Pediatrics II, University of Ulm, Federal Republic of Germany.
Bross-Bach U
Schmidt H
Waller H D
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21 references, click to expand
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Article Info
Journal
Blut
Abbr.
Blut
ISSN
0006-5242
DOI
10.1007/BF00320220
Published
1987-12-00
Pages
505-11
Language
English
Region
Germany
NLM ID
0173401
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00320220
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