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PMID: 348195 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

Genetic protein polymorphisms in human saliva: an interpretive review.

Biochemical genetics ·Vol. 16 ·No. 1-2 ·1978-02-00 ·Pages 79-99

Azen EA

Abstract

The purpose of this review is to summarize recent progress in the field of genetic protein polymorphisms found in human saliva since 1972. Prior to 1972 most of the investigations were related to amylase. The genetics of salivary amylase will not be considered here, since it has recently been thoroughly reviewed elsewhere (Merritt and Karn, 1977). In this review, special attention will be devoted to the complex interrelationships of the proline-rich (Pr), double-band (Db), acidic protein (Pa), and peroxidase (SAPX) systems. The biochemically related Pr, Db, and Pa systems show distinctive genetic patterns, and there are associations between the phenotypes indicating linkage relationships. There is also evidence for probable interaction of products of the Pa and SAPX loci. Electrophoretic properties of these proteins can be defined in several gel systems, permitting an accurate definition of phenotypes. The usefulness and limitations of the different gel systems in the interpretation of these electrophoretic patterns will be illustrated. Allelic frequencies of the systems to be discussed are given in Table I. To aid comprehension, the systems will be discussed in logical rather than historical sequence.

MeSH Terms
Acid Phosphatase/genetics Amylases/genetics Carboxylic Ester Hydrolases/genetics Gene Frequency Glucosephosphate Dehydrogenase/genetics Humans Peroxidases/genetics Polymorphism, Genetic Saliva/enzymology Salivary Proteins and Peptides/genetics
Chemicals
Salivary Proteins and Peptides Glucosephosphate Dehydrogenase Peroxidases Carboxylic Ester Hydrolases Acid Phosphatase Amylases
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Azen E A
References (38)
38 references, click to expand
  1. Genetic studies of human acidic salivary protein (Pa).
    Am J Hum Genet. 1975 May;27(3):292-303 PMID: 803012
  2. Human saliva esterases: genetic studies.
    Hum Hered. 1976;26(3):207-16 PMID: 955645
  3. A film detection method for tritium-labelled proteins and nucleic acids in polyacrylamide gels.
    Eur J Biochem. 1974 Jul 1;46(1):83-8 PMID: 4850204
  4. Genetic polymorphism of proline-rich human salivary proteins.
    Science. 1973 Jun 8;180(4090):1067-9 PMID: 4706325
  5. Histones isolated from human parotid fluid.
    Biochem Biophys Res Commun. 1973 Feb 5;50(3):676-82 PMID: 4689071
  6. Staining of phospho-proteins on acrylamide gel electropherograms.
    Anal Biochem. 1973 Aug;54(2):386-94 PMID: 4125088
  7. Immunological relationships and a genetic interpretation of major and minor acidic proteins in human parotid saliva.
    Biochem Genet. 1977 Jun;15(5-6):549-62 PMID: 560186
  8. Saliva acid phosphatases: genetic studies.
    Hum Hered. 1976;26(2):81-9 PMID: 950242
  9. Properties of salivary basic proteins showing polymorphism.
    Biochem Genet. 1973 May;9(1):69-86 PMID: 4197885
  10. The interaction of human parotid salivary proteins with hydroxyapatite.
    Arch Oral Biol. 1973 Dec;18(12):1517-29 PMID: 4522815
  11. Human Pb, human post-Pb, and nonhuman primate Pb proteins: immunological and biochemical relationships.
    Biochem Genet. 1977 Oct;15(9-10):947-62 PMID: 412494
  12. An improved method for the detection of anionic polymorphic proteins in human saliva on polyacrylamide slab gels.
    Anal Biochem. 1975 May 12;65(1-2):561-6 PMID: 236699
  13. The isolation from human parotid saliva of a further group of proline-rich proteins.
    Arch Oral Biol. 1974 Aug;19(8):627-32 PMID: 4532489
  14. Characterisation studies on the specific human salivary proteins adsorbed in vitro by hydroxyapatite.
    Caries Res. 1971;5(3):215-27 PMID: 5284350
  15. An autosomal glucose-6-phosphate dehydrogenase (hexose-6-phosphate dehydrogenase) polymorphism in human saliva.
    Hum Hered. 1976;26(2):113-23 PMID: 950237
  16. Chemical and physical characteristics of a phosphoprotein from human parotid saliva.
    Biochem J. 1975 Mar;145(3):557-67 PMID: 1156372
  17. Purification and partial characterization of four proteins from human parotid saliva.
    Biochem J. 1971 Jul;123(3):455-64 PMID: 5001593
  18. Proline-rich proteins from human parotid saliva. I. Isolation and partial characterization.
    Biochemistry. 1971 Nov;10(23):4233-8 PMID: 4331333
  19. Fractionation of human parotid salivary proteins and the isolation of an histidine-rich acidic peptide which shows high affinity for hydroxyapatite surfaces.
    Arch Oral Biol. 1975 Sep;20(9):553-8 PMID: 1058650
  20. Organic components of human parotid and submaxillary saliva.
    Ann N Y Acad Sci. 1965 Sep 30;131(2):802-11 PMID: 5214667
  21. The identification of a peptide in human parotid saliva particularly active in enhancing the glycolytic activity of the salivary micro-organisms.
    Biochem J. 1975 Aug;149(2):489-92 PMID: 1180910
  22. Antibacterial activity of the purified peroxidase from human parotid saliva.
    J Bacteriol. 1968 Sep;96(3):575-9 PMID: 4183966
  23. Salivary peroxidase (SAPX): genetic modification and relationship to the proline-rich (Pr) and acidic (Pa) proteins.
    Biochem Genet. 1977 Feb;15(1-2):9-29 PMID: 849256
  24. Differential staining of phosphoproteins on polyacrylamide gels with a cationic carbocyanine dye.
    Anal Biochem. 1973 Nov;56(1):43-51 PMID: 4128675
  25. Quantitative film detection of 3H and 14C in polyacrylamide gels by fluorography.
    Eur J Biochem. 1975 Aug 15;56(2):335-41 PMID: 1175627
  26. Salivary and pancreatic amylase: electrophoretic characterizations and genetic studies.
    Am J Hum Genet. 1973 Sep;25(5):510-22 PMID: 4741846
  27. Amino acid composition of human parotid salivary proteins selectively adsorbed by hydroxyapatite.
    Arch Oral Biol. 1970 Oct;15(10):1001-3 PMID: 5275746
  28. The isolation from human parotid saliva and partial characterization of the protein core of a major parotid glycoprotein.
    Arch Oral Biol. 1973 Jul;18(7):827-37 PMID: 4198619
  29. Dental phosphoprotein-induced formation of hydroxylapatite during in vitro synthesis of amorphous calcium phosphate.
    Biochemistry. 1976 Aug 10;15(16):3445-9 PMID: 952868
  30. Differential elution of histones from gel-trapped nuclei.
    Biopolymers. 1969;7(1):39-58 PMID: 5772420
  31. Genetic polymorphism of human salivary proline-rich proteins: further genetic analysis.
    Biochem Genet. 1974 Aug;12(2):109-20 PMID: 4424642
  32. Partial characterization of five glycoprotein fractions secreted by the human parotid glands.
    Arch Oral Biol. 1974 Oct;19(10):921-8 PMID: 4531851
  33. Isolation and partial characterization of human parotid basic proteins.
    Biochem Genet. 1977 Oct;15(9-10):925-46 PMID: 588241
  34. Partial purification and characterization of a polymorphic protein (Pa) in human parotid saliva.
    Am J Hum Genet. 1975 May;27(3):304-14 PMID: 803013
  35. Polymorphisms of human salivary proteins.
    Am J Hum Genet. 1974 Mar;26(2):145-53 PMID: 4823024
  36. The isolation of some basic proline-rich proteins from human parotid saliva.
    Arch Oral Biol. 1977;22(1):37-41 PMID: 266856
  37. Genetic polymorphism of basic proteins from parotid saliva.
    Science. 1972 May 12;176(4035):673-4 PMID: 17778168
  38. Studies on histidine-rich polypeptides from human parotid saliva.
    Arch Biochem Biophys. 1976 Dec;177(2):427-36 PMID: 1015827
Article Info
Journal
Biochemical genetics
Abbr.
Biochem Genet
ISSN
0006-2928
DOI
10.1007/BF00484386
Published
1978-02-00
Pages
79-99
Language
English
Region
United States
NLM ID
0126611
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00484386 View journal details
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