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PMID: 3485541 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Type IX collagen is a potent inducer of PGE2 and interleukin 1 production by human monocyte macrophages.

FEBS letters ·Vol. 198 ·No. 2 ·1986-03-31 ·Pages 208-12

Dayer JM, Ricard-Blum S, Kaufmann MT, Herbage D

Abstract

Type IX collagen and its collagenous fragments are potent stimulatory agents on human blood mononuclear cells for the production of prostaglandin E2 and interleukin 1/mononuclear cell factor. Type IX collagen is 2-4-fold more potent that type I and II and 1 alpha-, 2 alpha- and 3 alpha-collagens. This property may be important in the destructive process of cartilage in inflammatory diseases.

MeSH Terms

Cells, Cultured Collagen/pharmacology Dinoprostone Humans Interleukin-1/biosynthesis Macrophages/metabolism Monocytes/drug effects,metabolism Monokines Prostaglandins E/biosynthesis Protein Biosynthesis

Chemicals

Interleukin-1 Monokines Prostaglandins E Collagen Dinoprostone

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Dayer J M

Ricard-Blum S

Kaufmann M T

Herbage D

Article Info

Journal

FEBS letters

Abbr.

FEBS Lett

ISSN

0014-5793

DOI

10.1016/0014-5793(86)80406-9

Published

1986-03-31

Pages

208-12

Language

English

Region

England

NLM ID

0155157

Subset

External Links

PubMed source DOI: 10.1016/0014-5793(86)80406-9 View journal details

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Type IX collagen is a potent inducer of PGE2 and interleukin 1 production by human monocyte macrophages.

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