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PMID: 3485680 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Natural and recombinant human interleukin 1-beta is cytotoxic for human melanoma cells.

Journal of immunology (Baltimore, Md. : 1950) ·Vol. 136 ·No. 8 ·1986-04-15 ·Pages 3098-102

Lachman LB, Dinarello CA, Llansa ND, Fidler IJ

Abstract

Human peripheral blood monocytes stimulated with LPS were found to release an activity that was cytotoxic for the A375 melanoma. Biochemical and immunological characterization of the activity indicated that IL 1-beta was the cytotoxic agent. Human recombinant IL 1-beta, purified to homogeneity, was directly cytotoxic for A375. Tumor necrosis factor, also released by activated monocytes, was not cytotoxic for the A375 melanoma.

MeSH Terms

Antineoplastic Agents/isolation & purification,physiology Cell Line Culture Media Cytotoxicity Tests, Immunologic Cytotoxicity, Immunologic Dose-Response Relationship, Immunologic Glycoproteins/physiology Humans Interleukin-1/isolation & purification,physiology Melanoma/immunology Monocytes/metabolism Recombinant Proteins/isolation & purification,physiology Tumor Necrosis Factor-alpha

Chemicals

Antineoplastic Agents Culture Media Glycoproteins Interleukin-1 Recombinant Proteins Tumor Necrosis Factor-alpha

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Lachman L B

Dinarello C A

Llansa N D

Fidler I J

Article Info

Journal

Journal of immunology (Baltimore, Md. : 1950)

Abbr.

J Immunol

ISSN

0022-1767

Published

1986-04-15

Pages

3098-102

Language

English

Region

United States

NLM ID

2985117R

Subset

Grants

NIAID NIH HHS · AI 15614 · United States

NCI NIH HHS · CA 38043 · United States

External Links

PubMed source View journal details

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Natural and recombinant human interleukin 1-beta is cytotoxic for human melanoma cells.

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