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PMID: 3487504 Published · ppublish English Comparative Study Journal Article

Low responder MHC alleles for Tc recognition of influenza nucleoprotein.

Immunogenetics ·Vol. 23 ·No. 6 ·1986-00-00 ·Pages 379-84

Pala P, Askonas BA

Abstract

Since virus nucleoprotein is an important target antigen for anti-influenza cytotoxic T cells (Tc), we examined the genetics of Tc responses to this single viral protein to find three nonresponder alleles (Dd, Dk, and Kb) in three haplotypes and their recombinants so far tested. B10.A(5R) mice bearing nonresponder MHC class I antigen in the D and K regions show no anti-NP Tc responses, however they do show a strong A-virus cross-reactive anti-influenza cytotoxicity. The high frequency of nonresponsiveness to a single viral component, as compared with the entire virus, has implications for the development of simple vaccines.

MeSH Terms
Alleles Animals H-2 Antigens/genetics,immunology Influenza A virus/immunology Major Histocompatibility Complex Mice Mice, Inbred Strains/genetics,immunology Nucleocapsid Proteins Nucleoproteins/immunology RNA-Binding Proteins T-Lymphocytes, Cytotoxic/immunology Viral Core Proteins Viral Proteins/immunology
Chemicals
H-2 Antigens NP protein, Influenza A virus Nucleocapsid Proteins Nucleoproteins RNA-Binding Proteins Viral Core Proteins Viral Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Pala P
Askonas B A
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24 references, click to expand
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Article Info
Journal
Immunogenetics
Abbr.
Immunogenetics
ISSN
0093-7711
DOI
10.1007/BF00372670
Published
1986-00-00
Pages
379-84
Language
English
Region
United States
NLM ID
0420404
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00372670 View journal details
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