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PMID: 3488019 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

In vitro activity of the new macrolide antibiotic roxithromycin (RU 28965) against clinical isolates of Haemophilus influenzae.

Antimicrobial agents and chemotherapy ·Vol. 29 ·No. 5 ·1986-05-00 ·Pages 921-2

Jorgensen JH, Redding JS, Howell AW

Abstract

The in vitro activity of the new macrolide antibiotic roxithromycin (RU 28965) was compared with the activities of five other orally absorbable antimicrobial agents against 100 clinical isolates of Haemophilus influenzae. Roxithromycin MICs were generally twofold to fourfold higher than those of erythromycin; the MIC for 90% of the strains for roxithromycin was 8 micrograms/ml.

MeSH Terms
Anti-Bacterial Agents/pharmacology Haemophilus Infections/microbiology Haemophilus influenzae/drug effects Humans In Vitro Techniques Leucomycins/pharmacology Microbial Sensitivity Tests
Chemicals
Anti-Bacterial Agents Leucomycins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Jorgensen J H
Redding J S
Howell A W
References (7)
7 references, click to expand
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    Antimicrob Agents Chemother. 1983 Aug;24(2):209-15 PMID: 6638988
  2. In vitro comparison of the activity of RU 28965, a new macrolide, with that of erythromycin against aerobic and anaerobic bacteria.
    Antimicrob Agents Chemother. 1984 Apr;25(4):529-31 PMID: 6732223
  3. Comparative in vitro activities of aztreonam, ciprofloxacin, norfloxacin, ofloxacin, HR 810 (a new cephalosporin), RU28965 (a new macrolide), and other agents against enteropathogens.
    Antimicrob Agents Chemother. 1985 Mar;27(3):388-92 PMID: 3158276
  4. Penetration of amoxicillin, cefaclor, erythromycin-sulfisoxazole, and trimethoprim-sulfamethoxazole into the middle ear fluid of patients with chronic serous otitis media.
    J Infect Dis. 1982 Jun;145(6):815-21 PMID: 7200999
  5. Erythromycin concentrations in middle ear exudates.
    Pediatrics. 1971 Sep;48(3):417-22 PMID: 5094342
  6. Concentrations of antimicrobial agents in middle ear fluid, saliva and tears.
    Int J Pediatr Otorhinolaryngol. 1981 Dec;3(4):327-34 PMID: 6799415
  7. Effect of pH on the activity of erythromycin against 500 isolates of gram-negative bacilli.
    Appl Microbiol. 1970 Nov;20(5):754-6 PMID: 4991920
Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.29.5.921
Published
1986-05-00
Pages
921-2
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC284180
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.29.5.921 PMC Full Text View journal details
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